Molecular Diagnosis and Treatments of Diabetes Mellitus

Dear Colleagues,

In recent years, several studies conducted among different populations, as well as on mice, have revealed new knowledge about the role of neurotransmission and inflammation in type 2 diabetes mellitus (T2DM) that is not currently included in protocols.  

Thus, a more solid functional link between these neurotransmitters and markers of inflammation must be established. To better understand and describe this complex association, further large-scale studies among different patient groups are needed. 

Epidemiological studies have established an association between inflammatory molecular biomarkers and the occurrence of T2DM and its complications. Because fat cells, macrophages, and other immune cells in the expanding adipose tissue interact with each other, it seems that adipose tissue is a major source of these molecular biomarkers. The identification of key molecular triggers of inflammation in T2DM is still poorly understood. The inflammatory response probably plays a part in the development of T2DM by making insulin less effective. This is made worse when hyperglycemia is present, which makes diabetes complications worse over time. Targeting inflammatory molecular pathways could be a component of strategies to prevent and control diabetes and its associated complications. 

Serotonin, released by intestinal enterochromaffin cells, appears to regulate energy homeostasis through peripheral mechanisms. Serotonergic effects on energy balance leads to secondary effects on glucose homeostasis, based on a well-established link between obesity and insulin resistance.  

This Special Issue invites research papers to highlight the involved DM molecular markers and pathways and outline perspectives for personalized DM diagnosis and treatment. Systemizing reviews on these topics are also warmly welcome.

Dr. Mihail Virgil Boldeanu
Guest Editor

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• metabolic disorders
• diabetes mellitus
• inflammation
• neurotransmitter
• inflammatory biomarkers
• molecular target
• molecular diagnostics
• therapeutics
• insulin resistance