Special Issue "Molecular Pathogenesis of Neurodegenerative Diseases Targeting Early Diagnosis and Treatment"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (15 May 2021).
2. Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia
Interests: developmental neurobiology; neuroendocrinology; neurodegenerative diseases; Parkinson’s disease; preclinical diagnosis; preventive neuroprotective therapy
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The fight against neurodegenerative diseases (NDDs), such as Alzheimer's disease and Parkinson's disease, is a global challenge of the 21st century since these diseases lead to disability and death. This is due to late diagnosis and treatment that begins many years after the onset of the disease, at the loss of most specific neurons and depletion of neuroplasticity. Therefore, priorities in neuroscience include fundamental studies of the cellular and molecular mechanisms of early pathogenesis of NDDs and their peripheral manifestations targeting early diagnosis and preventive treatment. Modeling the progression of NDDs in animals is the only means we currently have to study the molecular mechanisms of neurodegeneration and neuroplasticity in the central and peripheral nervous system at the early stage of the disease. In turn, studies of early peripheral genetic and metabolic manifestations of NDDs are carried out not only in animal models, but also in humans—at the prodromal stage, diagnosed by early nonspecific symptoms, and at the early clinical stage, after the appearance of specific symptoms. Most of these studies are focused on changes in the chemical composition of bodily fluids (CSF, plasma, etc.), as well as changes in gene expression and the phenotype of peripheral cells (blood cells, skin cells, etc.). These findings are considered to be biochemical and biomolecular manifestations of the pathogenesis of NDDs and potential diagnostic markers. Fundamental knowledge of the cellular and molecular mechanisms underlying NDDs and the development of methods for early diagnosis may open up prospects for the use of preventive neuroprotective treatments that could slow down neurodegeneration and prolong the period of physical and social activity of subjects at risk.
Prof. Dr. Michael Ugrumov
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- neurodegenerative diseases
- Alzheimer's disease
- Parkinson’s disease
- animal models
- molecular mechanisms
- early diagnosis
- preventive treatment