Molecular Bases of Senescence
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 58883
Special Issue Editors
Interests: human muscle senescence; skeletal muscle physiology; adaptive responses to hypoxia and microgravity; growth factors and transcription factors in excitable cells; Oxidative stress; brain physiology: cognitive aspects
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2. Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
Interests: supplement; vitamin D; depression; dementia; Alzheimer; aging; oxidative stress; inflammation
Special Issues, Collections and Topics in MDPI journals
Interests: oxidative stress and antioxidant enzymes; cellular signalling; growth factors; muscular trophism; muscle stem cells; regenerative aspects of space flight; sarcopenia
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue aims to highlight the contributions of epigenetic and eugenic factors in establishing the longevity and life span of a living organism. The starting hypothesis, which is present in the scientific literature currently available, is that lifestyle and environmental factors play a preponderant role during the early stages of existence, whereas genetics becomes fundamental to establish the complete life span of an organism.
To verify this possibility, we propose gathering original contributions and analyses of data already present in the scientific literature concerning different aspects that form the basis of this theory. In particular:
- the presence or not of a unique centre able to determine the senescence of the whole organism
- the molecular effects of environmental inductors (oxidative stress, pro-inflammatory factors, caloric supply, nutrients, etc.);
- the different mechanisms: (a) cellular (proteostasis, autophagy, inflammation, etc.); (b) signalling (NF-kB, TOR, sirtuins, etc.); and (c) the intercellular pathways (localized growth factors, miRNA, etc.) able to accelerate or inhibit the aging process; and
- the aspects related to the senescence of the muscular apparatus (sarcopenia) and alterations of the nervous system (degeneration/regeneration ratio, brain areas with different sensitivities, etc.) including those of cognitive and pathological interest as well as the Alzheimer's disease and Parkinson’s disorder.
Prof. Dr. Giorgio Fanò-Illic
Prof. Dr. Patrizia Mecocci
Prof. Dr. Stefania Fulle
Guest Editors
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Keywords
- aging process
- oxidative stress
- proteostasis
- autophagy
- inflammation
- cellular signalling
- growth factors
- miRNA
- stem cells
- sarcopenia
- Alzheimer's disease
- Parkinson’s disorder
- nutrition
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