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Special Issue "Mitochondrial Stress in Non-alcoholic Fatty Liver Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 December 2019.

Special Issue Editors

Guest Editor
Prof. Dr. Paulo J. Oliveira

CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
E-Mail
Phone: +351-231-249-195
Interests: heart; liver; mitochondria; metabolism; mitochondria-targeted interventions; physical activity; apoptosis; biomarkers for mitochondrial dysfunction
Guest Editor
Prof. Dr. Joan Rosello-Catafau

Reperfusion Laboratory, Department of Experimental Pathology, Institut dÍnvestigacions Biomèdiques de Barcelona, Barcelona, Catalonia, Spain
E-Mail
Interests: heart; liver; pancreas; kidney; intestine; warm ischemia and reperfusion injury; organ transplantation (cold ischemia reperfusion injury); organ preservation solutions in static preservation; perfusate solutions in dynamic graft preservation; inflammation and apoptosis; mitochondrial and related markers and therapeutic strategies to prevent IRI
Guest Editor
Prof. Dr. Carlos Marques Palmeira

1. Department of Life Sciences, University of Coimbra, Portugal
2. CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Portugal
E-Mail
Interests: liver, muscle, adipose tissue; ischemia/reperfusion; mitochondria; steatosis; mitochondrial signalling and bioenergetics; mitochondrial dynamics; mitohormesis

Special Issue Information

Dear Colleagues

Despite over 30 years of major progress in the knowledge and management of liver disease, approximately 29 million people in the European Union currently suffer from a chronic liver condition, with cirrhosis and primary liver cancer representing the end-stage of liver pathology. The four leading causes of cirrhosis and primary liver cancer in Europe are harmful alcohol consumption, viral hepatitis B and C, and non-alcoholic fatty liver disease (NAFLD). The latter, encompassing non-alcoholic steatohepatitis (NASH), is now among the most prevalent chronic liver diseases, with particularly steep increases in Western Societies.

NAFLD has risen rapidly in parallel with the recent surge in obesity and Type 2 diabetes mellitus (T2DM). Available data suggests its prevalence rate to be 2–44% in the general European population and 42.6–69.5% in people with type 2 diabetes mellitus (T2DM). This wide range of estimates in part reflects the poor specificity and accuracy of current clinical screening methods. Moreover, there is no therapeutic consensus for NAFLD/NASH treatment at present, which is worsened by the fact that biomarkers that inform hepatic metabolic/mitochondrial function in NAFLD are lacking.  NAFLD is predicted to be the primary cause for liver transplants by 2020, representing a major potential threat to public health in Europe and in the world.  

Hence, novel and innovative NAFLD will reap substantial societal benefits and provide commercial opportunities. While NAFLD development involves the interplay of nutritional and intrinsic factors, the gut–liver axis and hepatic mitochondrial remodelling are two critical mediators in the overall process, which often are inter-connected but poorly explored. Mitochondrial stress responses are considered an important fulcrum of the progressive hepatic degeneration observed in NAFLD.

This Special Issue will publish top quality original papers, mini and full reviews, and perspectives based on basic and translational research, clinical implementation, technology development and transfer, and social outreach-focused papers.

The general premise of the research background for this special edition is that NAFLD pathogenesis and progression involves nutrient, inflammatory, and oxidative stress factors that directly or indirectly impair mitochondrial metabolic activity and energy generation in the liver, thus resulting in mitochondrial stress. Therefore, characterizing the underlying mechanisms of metabolic and gut-liver axis dysfunction, identifying biomarkers that inform mitochondrial/metabolic status, and designing interventions for restoration of normal metabolic activity in NAFLD patients are the central goals of this edition.

Prof. Dr. Paulo J. Oliveira
Prof. Dr. Joan Rosello-Catafau
Prof. Dr. Carlos Marques Palmeira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Open AccessArticle
Aspalathin-Enriched Green Rooibos Extract Reduces Hepatic Insulin Resistance by Modulating PI3K/AKT and AMPK Pathways
Int. J. Mol. Sci. 2019, 20(3), 633; https://doi.org/10.3390/ijms20030633
Received: 19 January 2019 / Accepted: 26 January 2019 / Published: 1 February 2019
Cited by 2 | PDF Full-text (2122 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells by modulating key effectors of insulin signalling such as phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK). However, the [...] Read more.
We previously demonstrated that an aspalathin-enriched green rooibos extract (GRE) reversed palmitate-induced insulin resistance in C2C12 skeletal muscle and 3T3-L1 fat cells by modulating key effectors of insulin signalling such as phosphatidylinositol-4,5-bisphosphate 3-kinase/protein kinase B (PI3K/AKT) and AMP-activated protein kinase (AMPK). However, the effect of GRE on hepatic insulin resistance is unknown. The effects of GRE on lipid-induced hepatic insulin resistance using palmitate-exposed C3A liver cells and obese insulin resistant (OBIR) rats were explored. GRE attenuated the palmitate-induced impairment of glucose and lipid metabolism in treated C3A cells and improved insulin sensitivity in OBIR rats. Mechanistically, GRE treatment significantly increased PI3K/AKT and AMPK phosphorylation while concurrently enhancing glucose transporter 2 expression. These findings were further supported by marked stimulation of genes involved in glucose metabolism, such as insulin receptor (Insr) and insulin receptor substrate 1 and 2 (Irs1 and Irs2), as well as those involved in lipid metabolism, including Forkhead box protein O1 (FOXO1) and carnitine palmitoyl transferase 1 (CPT1) following GRE treatment. GRE showed a strong potential to ameliorate hepatic insulin resistance by improving insulin sensitivity through the regulation of PI3K/AKT, FOXO1 and AMPK-mediated pathways. Full article
(This article belongs to the Special Issue Mitochondrial Stress in Non-alcoholic Fatty Liver Disease)
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Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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