Special Issue "Metformin: Mechanism and Application"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 July 2018)
Dr. Jolanta Weaver
Newcastle University, United Kingdom, Institute of Cellular Medicine/Cardiovascular Research Centre, Newcastle, UK
Website | E-Mail
Interests: cardiovascular disease; diabetes mellitus; vascular stem cells; endothelial progenitor cells; repurposing metformin for CVD; risk factors for CVD; in vitro models of CVD; clinical trials
Although metformin has been available for almost a century, Europe only discovered it 60 years ago. However, it took a further 38 years for America to appreciate its virtues. Metformin has been shown to be the first cardioprotective drug in type 2 diabetes, as born by UKPDS trial, and others that followed. The scientific interest in metformin has recently increased with a variety of tissues being studied, and use of metformin in a wide range of patients outside licensed indications. The pleiotrophic actions of metformin stretch from improving insulin resistance, membrane-related effects to cardioprotective mechanism via CD34+ umbilical cord blood stem cells and the reduction of myocardial infarct size. This Special Issue of the International Journal of Molecular Sciences has the aspiration of addressing (nonexclusively) the mechanisms of metformin action in different tissues from endothelial cells, hepatocytes, myocytes, cancer cells to clinical studies of translational design supported by laboratory investigations. The purpose of this issue is to focus on fundamental differences distinguishing tissue-specific effects and common themes related to metformin therapy in different patient groups. The appraisal of previous and current research on this compound is likely to benefit the future discoveries of novel applications of metformin.
Dr. Jolanta Weaver
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- energy metabolism
- endothelial cells
- cardiovascular disease