Cardiovascular Effects of Newer Glucose-Lowering Therapies: Molecular Mechanisms and Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 1
Special Issue Editors
Interests: rheumatoid arthritis; cardiovascular disease; cohort study; antiphospholipid syndrome; phospholipid antibody; prothrombin; maturity onset diabetes of the young; sodium glucose cotransporter 2; cardiovascular system
Special Issues, Collections and Topics in MDPI journals
Interests: type 2 diabetes mellitus; diabetic complications; cardiovascular disease; heart failure; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The emergence of sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and dual incretin receptor agonists has revealed unexpected cardioprotective properties that extend beyond glycemic regulation. While clinical trials have demonstrated reduced cardiovascular mortality and heart failure outcomes, the molecular underpinnings of these benefits remain incompletely understood. This Special Issue will focus on deciphering the molecular interactions and signaling pathways through which these therapies mediate cardiovascular protection.
We welcome studies elucidating drug–target interactions at atomic resolution, metabolic reprogramming in cardiac cells, and molecular crosstalk between glycemic control and cardiovascular homeostasis. Of particular interest are investigations in the following areas:
- Structural biology of drug–receptor complexes;
- Mitochondrial energetics and redox regulation;
- Inflammatory pathway modulation (NLRP3, NF-κB);
- Endothelial mechanotransduction and vascular signaling;
- The epigenetic regulation of cardiometabolic genes;
- Organelle-specific effects (e.g., sarcoplasmic reticulum, lysosomes);
- Novel molecular targets identified through omics approaches.
Dr. Paschalis Karakasis
Dr. Dimitrios Patoulias
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- sodium-glucose cotransporter 2 (SGLT2) inhibitors
- glucagon-like peptide-1 receptor agonists (GLP-1RAs)
- dual incretin receptor
- cardiovascular protection
- vascular signaling
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
