Cardiovascular Effects of Newer Glucose-Lowering Therapies: Molecular Mechanisms and Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 October 2025 | Viewed by 27
Special Issue Editors
Interests: rheumatoid arthritis; cardiovascular disease; cohort study; antiphospholipid syndrome; phospholipid antibody; prothrombin; maturity onset diabetes of the young; sodium glucose cotransporter 2; cardiovascular system
Special Issues, Collections and Topics in MDPI journals
Interests: type 2 diabetes mellitus; diabetic complications; cardiovascular disease; heart failure; chronic kidney disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The emergence of sodium-glucose cotransporter 2 (SGLT2) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1RAs), and dual incretin receptor agonists has revealed unexpected cardioprotective properties that extend beyond glycemic regulation. While clinical trials have demonstrated reduced cardiovascular mortality and heart failure outcomes, the molecular underpinnings of these benefits remain incompletely understood. This Special Issue will focus on deciphering the molecular interactions and signaling pathways through which these therapies mediate cardiovascular protection.
We welcome studies elucidating drug–target interactions at atomic resolution, metabolic reprogramming in cardiac cells, and molecular crosstalk between glycemic control and cardiovascular homeostasis. Of particular interest are investigations in the following areas:
- Structural biology of drug–receptor complexes;
- Mitochondrial energetics and redox regulation;
- Inflammatory pathway modulation (NLRP3, NF-κB);
- Endothelial mechanotransduction and vascular signaling;
- The epigenetic regulation of cardiometabolic genes;
- Organelle-specific effects (e.g., sarcoplasmic reticulum, lysosomes);
- Novel molecular targets identified through omics approaches.
Dr. Paschalis Karakasis
Dr. Dimitrios Patoulias
Guest Editors
Manuscript Submission Information
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Keywords
- sodium-glucose cotransporter 2 (SGLT2) inhibitors
- glucagon-like peptide-1 receptor agonists (GLP-1RAs)
- dual incretin receptor
- cardiovascular protection
- vascular signaling
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