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Molecule Research in Normal and Pathological Brain Aging

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (15 December 2023) | Viewed by 3903

Special Issue Editors


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Guest Editor
Departamento de Fisiología y Patología, Escuela de Medicina y Centro de Neurología Traslacional, Facultad de Medicina, Universidad de Valparaíso, Valparaíso 2360102, Chile
Interests: synaptic plasticity; calcium homeostasis; neuroinflammation; reactive oxygen species; neurodegenerative diseases; Alzheimer’s disease (AD)

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Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy
Interests: biochemistry; oxidative stress; inflammation; ischemic injury; neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The increase in the life expectancy of the population imposes new challenges to understand how in some individuals brain aging is associated with a higher prevalence of neurodegenerative diseases, while in others, neuronal functions remain intact for much longer. It has been found that different factors contribute to pathological aging, including the management of oxidative damage and neuroinflammation, which are key to the development of neurodegenerative diseases. In this Special Issue, we are gathering manuscripts (reviews and articles) about the physiological and pathophysiological mechanisms for aging brain, such as, synaptic plasticity, calcium homeostasis, neuroinflammation, and reactive oxygen species, among others. A particular focus will be on the discovery of novel molecular mechanistic insights for a neurodegenerative disease treatment. 

Dr. Pablo Munoz
Dr. Roberta Fusco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurodegenerative diseases
  • huntington
  • Alzheimer's disease (AD)
  • molecular mechanism
  • therapy

Published Papers (1 paper)

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Review

36 pages, 1527 KiB  
Review
A Role for Advanced Glycation End Products in Molecular Ageing
by Katarzyna Zgutka, Marta Tkacz, Patrycja Tomasiak and Maciej Tarnowski
Int. J. Mol. Sci. 2023, 24(12), 9881; https://doi.org/10.3390/ijms24129881 - 8 Jun 2023
Cited by 15 | Viewed by 3491
Abstract
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ and whole-body levels. These changes result in decreased functioning of the organism and the development of certain conditions, which ultimately lead to an increased risk of death. Advanced glycation [...] Read more.
Ageing is a composite process that involves numerous changes at the cellular, tissue, organ and whole-body levels. These changes result in decreased functioning of the organism and the development of certain conditions, which ultimately lead to an increased risk of death. Advanced glycation end products (AGEs) are a family of compounds with a diverse chemical nature. They are the products of non-enzymatic reactions between reducing sugars and proteins, lipids or nucleic acids and are synthesised in high amounts in both physiological and pathological conditions. Accumulation of these molecules increases the level of damage to tissue/organs structures (immune elements, connective tissue, brain, pancreatic beta cells, nephrons, and muscles), which consequently triggers the development of age-related diseases, such as diabetes mellitus, neurodegeneration, and cardiovascular and kidney disorders. Irrespective of the role of AGEs in the initiation or progression of chronic disorders, a reduction in their levels would certainly provide health benefits. In this review, we provide an overview of the role of AGEs in these areas. Moreover, we provide examples of lifestyle interventions, such as caloric restriction or physical activities, that may modulate AGE formation and accumulation and help to promote healthy ageing. Full article
(This article belongs to the Special Issue Molecule Research in Normal and Pathological Brain Aging)
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