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Cancer Chemoprevention by Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1389

Special Issue Editor


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Guest Editor
Institute of Physiology, University of Pécs, Pécs, Hungary
Interests: nutrition science; chemical carcinogens toxicology; chemoprevention; environmental pollution; epigenetics; radioactivity; nanomolecules

Special Issue Information

Dear Colleagues,

There has been a staggering and constant rise in the number of cancer patients globally in recent years. It is also postulated that cancer mortality rates will potentially increase with the increasing aging societies in the future. Though cancer is a deadly disease, almost half of all cancer-related deaths could be prevented by avoiding risk factors. Furthermore, with the help of epigenetic and genomic technologies, individual susceptibility can be determined rather precisely which could help in taking the necessary precautionary measures.

Scientific evidence points toward the tumorigenic effects caused by cancer, in which nutritional factors play a crucial role. Thus, research has been carried out highlighting the anti-tumor effects of a healthy diet, wherein the phytonutrients derived from natural sources are considered the most important elements.

This Special Issue aims to focus on research pertaining to the discovery of new molecular biological correlations describing the anti-tumor effects of phytonutrients, reaction mechanisms and cell culture, which will allow us to further develop chemopreventive strategies. We will welcome animal experimental and human epidemiological studies, biomolecular experiments or modeling, as well as review articles.

Dr. Ferenc Budán
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • cancer
  • chemoprevention
  • phytomedicine
  • carcinogenesis
  • gene expression
  • biomolecules
  • molecular mechanisms

Published Papers (1 paper)

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Research

16 pages, 7113 KiB  
Article
Hinokitiol Inhibits Breast Cancer Cells In Vitro Stemness-Progression and Self-Renewal with Apoptosis and Autophagy Modulation via the CD44/Nanog/SOX2/Oct4 Pathway
by Yi-Fen Chiang, Ko-Chieh Huang, Hsin-Yuan Chen, Nadia M. Hamdy, Tsui-Chin Huang, Hsin-Yi Chang, Tzong-Ming Shieh, Yun-Ju Huang and Shih-Min Hsia
Int. J. Mol. Sci. 2024, 25(7), 3904; https://doi.org/10.3390/ijms25073904 - 31 Mar 2024
Cited by 1 | Viewed by 1102
Abstract
Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing to tumorigenicity. Therefore, comprehending the characteristics of stemness progression and the underlying molecular mechanisms is pivotal for BC [...] Read more.
Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing to tumorigenicity. Therefore, comprehending the characteristics of stemness progression and the underlying molecular mechanisms is pivotal for BC advancement. Hinokitiol (β-thujaplicin), a tropolone-related compound abundant in the heartwood of cupressaceous plants, exhibits antimicrobial activity. In our study, we employed three BC cell lines (MDA-MB-231, MCF-7, and T47D) to assess the expression of stemness-, apoptosis-, and autophagy-related proteins. Hinokitiol significantly reduced the viability of cancer cells in a dose-dependent manner. Furthermore, we observed that hinokitiol enhances apoptosis by increasing the levels of cleaved poly-ADP-ribose polymerase (PARP) and phospho-p53. It also induces dysfunction in autophagy through the upregulation of LC3B and p62 protein expression. Additionally, hinokitiol significantly suppressed the number and diameter of cancer cell line spheres by reducing the expression of cluster of differentiation44 (CD44) and key transcription factors. These findings underscore hinokitiol’s potential as a therapeutic agent for breast cancer, particularly as a stemness-progression inhibitor. Further research and clinical studies are warranted to explore the full therapeutic potential of hinokitiol in the treatment of breast cancer. Full article
(This article belongs to the Special Issue Cancer Chemoprevention by Natural Products)
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