Special Issue "G Protein-Coupled Receptor and Their Kinases in Cell Biology and Disease"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 14506
Interests: heart failure; cardiovascular disease; G protein coupled receptor; Ischemia; neurodegeneration; periodontitis; inflammation; metabolism; pharmacology; gene-therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue in International Journal of Molecular Sciences: G Protein-Coupled Receptor and Their Kinases in Cell Biology and Disease 2.0
Special Issue in International Journal of Molecular Sciences: Kinase and GPCR Drug Discovery
Special Issue in International Journal of Molecular Sciences: Molecular Mechanisms Underlying Chronic and Degenerative Diseases
Topical Collection in International Journal of Molecular Sciences: G Protein-Coupled Receptor and Their Kinases in Cell Biology and Disease
Over the past three decades, after that Nobel prizes Robert Lefkowitz and Brian Kobilka characterized G protein-coupled receptors (GPCRs) structure, several clinical and pharmacological evidence advanced our knowledge on how these receptors, and their signaling pathways, influence almost every aspect of mammals physiology. Indeed, GPCRs can transduce cellular signals from neurohormones, sensory stimuli, and ions and their activity is directly modulated by GPCR kinases (GRKs) by phosphorylation and subsequent desensitization. Nevertheless, an alteration in GRKs expression, with subsequent GPCR dysfunction, may induce, or at least influence, the development and progression of different systemic disorders. Thus, several drugs able to directly inhibit or enhance GPCR signaling have been developed and are currently used in clinical practice.
This Special Issue is calling both original articles and reviews providing to the readers of IJMS a comprehensive elucidation about GPCR and GRK functions in cell biology necessary for developing novel research approaches as well as therapeutic strategies.
Dr. Cannavo Alessandro
Manuscript Submission Information
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- Cell Biology
- Cardiovascular Disease
- G protein coupled receptor
- GRK Ischemia