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Special Issue "Neurotransmitters and Neuropeptides in the Modulation of the Carotid Body"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Prof. Dr. Andrea Porzionato
Guest Editor
Section of Human Anatomy, Department of Neuroscience, University of Padova, Padova, Italy
Interests: neuroscience; neuroanatomy; peripheral arterial chemoreceptors; carotid body; neuropeptides; receptors; hyperoxia; hypoxia; plasticity; clinical anatomy

Special Issue Information

Dear Colleagues,

This Special Issue will cover a selection of recent research topics and current review articles related to the role of neurotransmitters and neuropeptides in the carotid body function and plasticity, also with reference to its more recent translational implications. Up-to-date review articles, commentaries, and experimental papers are all welcome.

The carotid body is the main peripheral arterial chemoreceptor, sensitive to hypoxia, hypercapnia and reduction in pH, but also to inflammatory and metabolic factors. Its stimulation induces increases in ventilatory frequency and volume, through activation of the medullary respiratory centers and sympathoactivation. The carotid body is structurally composed of chemosensitive type I cells and supportive type II cells, the latter being also identified as stem cell precursors for type I cells. A large number of neurotransmitters and neuropeptides (with their receptors) have been identified in the carotid body; they are involved in the modulation of chemoreception and in plasticity responses of the carotid body to environmental factors such as hypoxia (continuous or intermittent), hyperoxia or inflammation. Accordingly, a role for the carotid body has been suggested in various clinical conditions, such as obesity, diabetes, hypertension, heart failure, obstructive sleep apnea, and sudden infant death syndrome.

Prof. Dr. Andrea Porzionato
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • peripheral arterial chemoreceptors
  • oxygen homeostasis
  • neurotransmitters
  • neuropeptides
  • growth factors
  • receptors
  • hypoxia
  • development
  • plasticity

Published Papers (1 paper)

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Open AccessReview
Vasoactive Intestinal Polypeptide in the Carotid Body—A History of Forty Years of Research. A Mini Review
Int. J. Mol. Sci. 2020, 21(13), 4692; https://doi.org/10.3390/ijms21134692 - 30 Jun 2020
Vasoactive intestinal polypeptide (VIP) consists of 28 amino acid residues and is widespread
in many internal organs and systems. Its presence has also been found in the nervous structures
supplying the carotid body not only in mammals but also in birds and amphibians. [...] Read more.
Vasoactive intestinal polypeptide (VIP) consists of 28 amino acid residues and is widespread
in many internal organs and systems. Its presence has also been found in the nervous structures
supplying the carotid body not only in mammals but also in birds and amphibians. The number
and distribution of VIP in the carotid body clearly depends on the animal species studied;
however, among all the species, this neuropeptide is present in nerve fibers around blood vessels
and between glomus cell clusters. It is also known that the number of nerves containing VIP located
in the carotid body may change under various pathological and physiological factors. The knowledge
concerning the functioning of VIP in the carotid body is relatively limited. It is known that VIP may
impact the glomus type I cells, causing changes in their spontaneous discharge, but the main impact
of VIP on the carotid body is probably connected with the vasodilatory eects of this peptide and its
influence on blood flow and oxygen delivery. This review is a concise summary of forty years of
research concerning the distribution of VIP in the carotid body. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1)    Andrea Porzionato
An Update On Growth And Trophic Factors In The Carotid Body

2)    Andrea Porzionato
Article on Receptor-Receptor Interactions

3)    Colin Nurse
Expanding role of dopaminergic inhibition in chemosensory functions of the rat carotid body: Potential Involvement of type II glial cells

4)    Silvia Conde
Exploring the mediators that promote carotid body overactivation in metabolic diseases

5)    Christopher Wyatt
Ethanol and Opioids do not act Synergistically to Depress Excitation in Carotid Body Type I cells

6)    Lopez Barneo + Ricardo Pardal
Neurotrasmitter modulation of proliferation and differentiation of CB progenitors

7)    Camillo Di Giulio
Similarities and controversia between carotid body and olfactory system

8)   Vsevolod Y. Polotsky
Metabolic Regulation of the Carotid Body Function

9)   Albert Dahan
Paralyzing the carotid bodies: a scoping review on the effects of muscle relaxants on peripheral chemosensitivity

10)   Andrew Holmes
G-protein modulation of carotid body responses to hypoxia and hypercapnia

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