Special Issue "Neurotransmitters and Neuropeptides in the Modulation of the Carotid Body"
Deadline for manuscript submissions: 30 September 2020.
Interests: neuroscience; neuroanatomy; peripheral arterial chemoreceptors; carotid body; neuropeptides; receptors; hyperoxia; hypoxia; plasticity; clinical anatomy
This Special Issue will cover a selection of recent research topics and current review articles related to the role of neurotransmitters and neuropeptides in the carotid body function and plasticity, also with reference to its more recent translational implications. Up-to-date review articles, commentaries, and experimental papers are all welcome.
The carotid body is the main peripheral arterial chemoreceptor, sensitive to hypoxia, hypercapnia and reduction in pH, but also to inflammatory and metabolic factors. Its stimulation induces increases in ventilatory frequency and volume, through activation of the medullary respiratory centers and sympathoactivation. The carotid body is structurally composed of chemosensitive type I cells and supportive type II cells, the latter being also identified as stem cell precursors for type I cells. A large number of neurotransmitters and neuropeptides (with their receptors) have been identified in the carotid body; they are involved in the modulation of chemoreception and in plasticity responses of the carotid body to environmental factors such as hypoxia (continuous or intermittent), hyperoxia or inflammation. Accordingly, a role for the carotid body has been suggested in various clinical conditions, such as obesity, diabetes, hypertension, heart failure, obstructive sleep apnea, and sudden infant death syndrome.
Prof. Dr. Andrea Porzionato
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- peripheral arterial chemoreceptors
- oxygen homeostasis
- growth factors
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
An Update On Growth And Trophic Factors In The Carotid Body
2) Andrea Porzionato
Article on Receptor-Receptor Interactions
3) Colin Nurse
Expanding role of dopaminergic inhibition in chemosensory functions of the rat carotid body: Potential Involvement of type II glial cells
4) Silvia Conde
Exploring the mediators that promote carotid body overactivation in metabolic diseases
5) Christopher Wyatt
Ethanol and Opioids do not act Synergistically to Depress Excitation in Carotid Body Type I cells
6) Lopez Barneo + Ricardo Pardal
Neurotrasmitter modulation of proliferation and differentiation of CB progenitors
7) Camillo Di Giulio
Similarities and controversia between carotid body and olfactory system
8) Vsevolod Y. Polotsky
Metabolic Regulation of the Carotid Body Function
9) Albert Dahan
Paralyzing the carotid bodies: a scoping review on the effects of muscle relaxants on peripheral chemosensitivity
10) Andrew Holmes
G-protein modulation of carotid body responses to hypoxia and hypercapnia