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Open AccessReview

Vasoactive Intestinal Polypeptide in the Carotid Body—A History of Forty Years of Research. A Mini Review

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowski Str. 13, 10-718 Olsztyn, Poland
Int. J. Mol. Sci. 2020, 21(13), 4692; https://doi.org/10.3390/ijms21134692
Received: 26 May 2020 / Revised: 29 June 2020 / Accepted: 30 June 2020 / Published: 30 June 2020
Vasoactive intestinal polypeptide (VIP) consists of 28 amino acid residues and is widespread
in many internal organs and systems. Its presence has also been found in the nervous structures
supplying the carotid body not only in mammals but also in birds and amphibians. The number
and distribution of VIP in the carotid body clearly depends on the animal species studied;
however, among all the species, this neuropeptide is present in nerve fibers around blood vessels
and between glomus cell clusters. It is also known that the number of nerves containing VIP located
in the carotid body may change under various pathological and physiological factors. The knowledge
concerning the functioning of VIP in the carotid body is relatively limited. It is known that VIP may
impact the glomus type I cells, causing changes in their spontaneous discharge, but the main impact
of VIP on the carotid body is probably connected with the vasodilatory eects of this peptide and its
influence on blood flow and oxygen delivery. This review is a concise summary of forty years of
research concerning the distribution of VIP in the carotid body. View Full-Text
Keywords: vasoactive intestinal polypeptide; carotid body; nerve fibers; innervation vasoactive intestinal polypeptide; carotid body; nerve fibers; innervation
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Gonkowski, S. Vasoactive Intestinal Polypeptide in the Carotid Body—A History of Forty Years of Research. A Mini Review. Int. J. Mol. Sci. 2020, 21, 4692.

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