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Open AccessArticle

Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment

Division of Endocrinology and Metabolism, Department of Internal Medicine, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan
Department of Clinical Pathology, Chi Mei Medical Center, Liouying 736 Taiwan
Department of Medical Research, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi City 600, Taiwan
Department of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Hsiang-Hsun Chuang had passed away.
Int. J. Mol. Sci. 2019, 20(21), 5315;
Received: 11 September 2019 / Revised: 21 October 2019 / Accepted: 21 October 2019 / Published: 25 October 2019
Aloperine, an alkaloid isolated from Sophora alopecuroides, exhibits multiple pharmacological activities including anti-inflammatory, antioxidant, antiallergic, antinociceptive, antipathogenic, and antitumor effects. Furthermore, it exerts protective effects against renal and neuronal injuries. Several studies have reported antitumor effects of aloperine against various human cancers, including multiple myeloma; colon, breast, and prostate cancers; and osteosarcoma. Cell cycle arrest, apoptosis induction, and tumorigenesis suppression have been demonstrated following aloperine treatment. In a previous study, we demonstrated antitumor effects of aloperine on human thyroid cancer cells through anti-tumorigenesis and caspase-dependent apoptosis induction via the Akt signaling pathway. In the present study, we demonstrated the modulation of the autophagy mechanism following the incubation of multidrug-resistant papillary and anaplastic human thyroid cancer cells with aloperine; we also illustrate the underlying mechanisms, including AMPK, Erk, JNK, p38, and Akt signaling pathways. Further investigation revealed the involvement of the Akt signaling pathway in aloperine-modulated autophagy in human thyroid cancer cells. These results indicate a previously unappreciated function of aloperine in autophagy modulation in human thyroid cancer cells. View Full-Text
Keywords: aloperine; thyroid cancer; autophagy aloperine; thyroid cancer; autophagy
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Yu, H.-I.; Shen, H.-C.; Chen, S.-H.; Lim, Y.-P.; Chuang, H.-H.; Tai, T.-S.; Kung, F.-P.; Lu, C.-H.; Hou, C.-Y.; Lee, Y.-R. Autophagy Modulation in Human Thyroid Cancer Cells following Aloperine Treatment. Int. J. Mol. Sci. 2019, 20, 5315.

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