Oxidants and Antioxidants in Molecular Sciences: 96 Years Anniversary since the Discovery of Folin-Ciocalteu Reagent
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 781
Special Issue Editors
Interests: pharmacy; pharmacology; public health; medicine; chemistry; clinical trials; nutrition; polyphenols; oxidative stress; antioxidants
Special Issues, Collections and Topics in MDPI journals
Interests: physiology; diabetes mellitus; metabolic diseases; obesity; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress significantly impacts the normal activity of various molecules, and a large number of pathologies are a consequence of this pathophysiological process. Lipids are prone to the process of lipid peroxidation, proteins (especially those that include in their structure cysteine and methionine) are susceptible to reactive oxygen species, and DNA can suffer profound modifications such as base modifications or single- and double-strand break. The measurement of phenolic compounds in a solution by using Folin–Ciocalteu reagent, a method invented by Otto Folin and Vintila Ciocalteu in 1927, opened the door for the development of oxidative stress and antioxidant capacity assays, including the direct measurement of reactive oxygen species, determination of protein carbonyl, malondialdehyde determination for assessing lipid peroxidation, determination of DNA damage by assessing the level of 8-hydroxy-2-deoxyguanosine, determination of total plasma antioxidant capacity, or determination of glutathione synthetase levels. The current Special Issue aims to promote the investigation of the correlation between the intensity of activity stress measured by classical or modern methods and the activation of certain molecular pathways: proinflammatory, pro-atherogenic or pro-oncogenic. Additionally, our aim is to investigate the in vivo and in vitro impact of supplementation with certain antioxidant substances on lipid and protein function as well as on different molecular pathways.
Prof. Dr. Simona Gabriela Bungau
Dr. Cosmin Mihai Vesa
Guest Editors
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Keywords
- oxidative stress
- antioxidants
- methods for determining oxidative stress
- lipid peroxidation
- protein oxidation
- Folin–Ciocalteu method
- oxidative stress impact on health
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