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Nutraceuticals in Human Diseases: Metabolism and Interactions

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 January 2023) | Viewed by 12300

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Special Issue Editors

Prof. Dr. Simona Gabriela Bungau

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Guest Editor

Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania
Interests: pharmacy; pharmacology; public health; medicine; chemistry; clinical trials; nutrition; polyphenols; oxidative stress; antioxidants
Special Issues, Collections and Topics in MDPI journals

Dr. Tapan Behl

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Guest Editor

Department of Pharmacology, Chitkara College of Pharmacy, Chitkara University, Punjab, India
Interests: molecular pharmacology; herbal drugs; unconventional therapies
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In these tough times, where people have numerous metabolic disorders due to faulty and stressful lifestyles, a hike in diseased population is noted. This is making people drift towards healthier alternatives and nutraceuticals as an emerging remedy for the prevention of diseases. Nutraceuticals are products of food or food compounds which possess health beneficiary activities. They range from genetically designed food compounds to nutrient supplements that are derived from the extraction of herbal plants, fruits, vegetables and cereals and other processed foods. They are mainly identified as sources of vitamins, minerals and amino acids and are used in an amplified manner for their tendency to effectively aid ailing metabolic and lifestyle disorders. Research throughout the globe is being conducted to elucidate lead molecules from traditional plants that possess therapeutic properties and can be used strategically in the management of metabolic diseases due to their significant role in depicting pathologies.

Prof. Dr. Simona Bungau
Dr. Tapan Behl
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nutraceuticals
metabolic disorders
therapeutics
interactions
pathology
nutrients
supplements
chronic diseases
herbals

Published Papers (3 papers)

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Research

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17 pages, 5079 KiB

Open AccessArticle

Fructose-Rich Diet Is a Risk Factor for Metabolic Syndrome, Proximal Tubule Injury and Urolithiasis in Rats

by Mariusz Flisiński, Andrzej Brymora, Natalia Skoczylas-Makowska, Anna Stefańska and Jacek Manitius

Int. J. Mol. Sci. 2022, 23(1), 203; https://doi.org/10.3390/ijms23010203 - 24 Dec 2021

Cited by 7 | Viewed by 2824

Abstract

Excessive consumption of fructose (FR) leads to obesity, metabolic syndrome (MS) and insulin resistance, which are known risk factors for kidney stones. The epidemiological study has suggested the association between fructose consumption and urolithiasis, but the precise mechanism is still not well understood. Male Wistar rats were assigned for 8 weeks to three groups with different FR content in diet: RD (n = 5)—regular diet with a FR < 3%; F10 (n = 6)—regular diet with an addition of 10% Fr in drinking water; F60 (n = 5)—60% FR as a solid food. Serum concentration of FR, creatinine (Cr), insulin (Ins), triglycerides (Tg), homocysteine (HCS), uric acid (UA), calcium (Ca), phosphate (Pi), magnesium (Mg) and sodium (Na) were measured. Based on 24 h urine collection the following tests were performed: urine pH, proteinuria (PCR), excretion of N-Acetyl-(D)-Glucosaminidase (NAG), monocyte chemoattractant protein (MCP-1), uric acid (uUAEx), phosphate (uPiEx), calcium (uCaEx), magnesium (uMgEx) and sodium (uNaEx). The creatinine clearance (CrCl) was calculated. Calcium deposits in kidney sections were examined using hematoxylin and eosin (HE) and von Kossa stains. The rats on F10 and F60, as compared to the RD diet, showed a tendency for lower CrCl, higher HCS level and some features of MS as higher Ins and TG levels. Interestingly, F10 (fluid) versus F60 (solid) diet led to higher serum Ins levels. F10 and F60 versus RD demonstrated higher urinary excretion of MCP-1 and NAG which were suggestive for inflammatory injury of the proximal tubule. F10 and F60 as compared to RD showed significantly lower uUAEx, although there were no differences in clearance and fractional excretion of UA. F60 versus RD induced severe phosphaturia (>30×) and natriuria (4×) and mild calciuria. F10 versus RD induced calciuria (3×), phosphaturia (2×) and mild natriuria. Calcium phosphate stones within the tubules and interstitium were found only in rats on FR diet, respectively, in two rats from the F10 group and another two in the F60 group. The rats which developed stones were characterized by significantly higher serum insulin concentration and urinary excretion of calcium and magnesium. A fructose-rich diet may promote development of calcium stones due to proximal tubule injury and metabolic syndrome. Full article

(This article belongs to the Special Issue Nutraceuticals in Human Diseases: Metabolism and Interactions)

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Review

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18 pages, 1963 KiB

Open AccessReview

Dietary Supplementation with Vitamin D, Fish Oil or Resveratrol Modulates the Gut Microbiome in Inflammatory Bowel Disease

by Vivian Naa Amua Wellington, Vijaya Lakshmi Sundaram, Soudamani Singh and Uma Sundaram

Int. J. Mol. Sci. 2022, 23(1), 206; https://doi.org/10.3390/ijms23010206 - 24 Dec 2021

Cited by 16 | Viewed by 5239

Abstract

Gastrointestinal health is influenced by the functional genes and metabolites generated by the human microbiome. As the volume of current biomedical and translational research indicates, the importance and impact of this ecosystem of microorganisms, especially those comprising the gut microbiome on human health, has become increasingly apparent. Changes to the gut microbiome are associated with inflammatory bowel disease (IBD), which is characterized by persistent intestinal inflammation. Furthermore, the lifetime dietary choices of their host may positively or negatively affect both the gut microbiome and its impact on IBD. As such, “anti-inflammatory” dietary supplements, their impact, and mechanisms in restoring gut microbiota homeostasis during IBD is an area of intensive research. Dietary supplementation may represent an important adjuvant treatment avenue for limiting intestinal inflammation in IBD. Overall, this review addresses the development of the gut microbiome, the significance of the gut microbiome in IBD, and the use of dietary supplements such as vitamin D, fish oil, and resveratrol in the mitigation of IBD-associated gut dysbiosis and intestinal inflammation. Full article

(This article belongs to the Special Issue Nutraceuticals in Human Diseases: Metabolism and Interactions)

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25 pages, 661 KiB

Open AccessReview

Sanguiins—Promising Molecules with Broad Biological Potential

by Jakub Gesek, Katarzyna Jakimiuk, Atanas G. Atanasov and Michał Tomczyk

Int. J. Mol. Sci. 2021, 22(23), 12972; https://doi.org/10.3390/ijms222312972 - 30 Nov 2021

Cited by 7 | Viewed by 2728

Abstract

Compounds of natural origin, an infinite treasure of bioactive chemical entities, persist as an inexhaustible resource for discovering new medicines. In this review, we summarize the naturally occurring ellagitannins, sanguiins, which are bioactive constituents of various traditional medicinal plants, especially from the Rosaceae family. In-depth studies of sanguiin H-6 as an antimicrobial, antiviral, anticancer, anti-inflammatory, and osteoclastogenesis inhibitory agent have led to potent drug candidates. In addition, recently, virtual screening studies have suggested that sanguiin H-6 might increase resistance toward SARS-CoV-2 in the early stages of infection. Further experimental investigations on ADMET (absorption, distribution, metabolism, excretion, and toxicity) supplemented with molecular docking and molecular dynamics simulation are still needed to fully understand sanguiins’ mechanism of action. In sum, sanguiins appear to be promising compounds for additional studies, especially for their application in therapies for a multitude of common and debilitating ailments. Full article

(This article belongs to the Special Issue Nutraceuticals in Human Diseases: Metabolism and Interactions)

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