Special Issue "Biologically Active Substances in Cardiovascular and Neurological Diseases"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: xenobiotic-associated cerebrovascular damage; ischemic stroke; diabetic vascular dysfunction; drug development
Interests: neuroprotection and neuroregeneration; electroceuticals; stroke clinical trials; animal and cellular models of stroke and neuroinflammation; novel drug delivery (nanotechnology and exosomes)
The incidence and prevalence of chronic diseases such as heart disease and diabetes, and neurodegenerative diseases such as Alzheimer’s disease, have been increasing throughout the world. This trend coincides with changes in lifestyle and chronic exposure to risk factors including environmental pollutants. Interestingly, there has been increasing attention regarding a connection between the heart and the brain, and the current evidence supports an association between cardiovascular (heart diseases, diabetes, stroke, and vascular diseases) and neurological diseases (neurovascular and neurodegenerative diseases).
The number of studies on naturally occurring bioactive substances has risen exponentially in recent decades, especially regarding their protective effects against oxidant stress or inflammatory signaling, which are the common underlying mechanisms for various chronic diseases including cardiovascular and neurological diseases. The characterization of the specific modes of action of bioactive substances in targeting certain pathological processes in specific diseases has also received much attention. Derivatization or pharmaceutical modification of the original natural compounds are important approaches to increase the bioactivity of naturally occurring substances. Bioactive substances in foods, such as nutraceuticals, can also be promising agents to study, considering their role in the maintenance of homeostasis in health.
This Special Issue will cover a selection of research papers and reviews that expand knowledge about the potential of naturally occurring bioactive compounds in health and chronic diseases, specifically focusing on the cardiovascular and neurological diseases. We also welcome studies on the elucidation of bioactive mechanisms of natural products against these diseases, enhancement of bioactivity via pharmaceutical formulation or derivatization of known bioactive substances, as well as on the identification of novel bioactive compounds.
Prof. Dr. Ok-Nam Bae
Prof. Dr. Arshad Majid
Prof. Dr. Rajanikant G K
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- chronic diseases
- natural products
- bioactive substances
- drug discovery
- derivatives of natural substances
- pharmaceutical formulation of bioactive substances