Cardiovascular Disease: Molecular Pathologies, and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2025) | Viewed by 807
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cardiovascular disease (CVD) involves conditions including coronary artery disease, hypertension, and heart failure, and it is a leading cause of global mortality. At the molecular level, atherosclerosis plays a central role, driven by dysregulated lipid metabolism, chronic inflammation, and endothelial dysfunction. Genetic factors, such as mutations in genes related to lipid metabolism, also contribute to CVD risk.
Understanding these molecular mechanisms is crucial for developing more effective treatments for CVD. This Special Issue will focus on key areas such as the role of lipid metabolism dysregulation, chronic inflammation, and endothelial dysfunction in atherosclerosis; the impact of Renin–Angiotensin–Aldosterone System (RAAS) overactivation in hypertension; and the contribution of myocardial fibrosis and neurohormonal imbalances to heart failure. Additionally, it will address genetic factors influencing CVD risk and the implications for personalized medicine. Apart from develop diagnostic tools, we aim to highlight innovative therapeutic strategies that target these molecular pathways, including novel pharmacological interventions, gene therapies, and lifestyle modifications.
Dr. Vaia Lambadiari
Guest Editor
Manuscript Submission Information
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Keywords
- endothelial dysfunction
- lipids
- inflammation
- genetic mutations
- atherosclerosis
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