ijerph-logo

Journal Browser

Journal Browser

Neonatal Infections: Challenges and Opportunities in Treatment and Prevention

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Global Health".

Deadline for manuscript submissions: closed (15 November 2020) | Viewed by 2365

Special Issue Editor


E-Mail Website
Guest Editor
Section of Neonatology, Department of Pediatrics Baylor College of Medicine & Texas Children's Hospital, Houston, TX 77030, USA
Interests: neonatal infections and immunity; systematic reviews; evidence based medicine; best evidence in medical education

Special Issue Information

Dear Colleagues,

We intend to organize a Special Issue on “Neonatal Infections: Challenges and Opportunities in Treatment and Prevention” in the International Journal of Environmental Research and Public Health. The Special Issue will be published in a peer-reviewed scientific journal that publishes articles and communications in the interdisciplinary area of environmental health sciences and public health. For detailed information on the journal, we refer you to https://www.mdpi.com/journal/ijerph

Approximately 2.5 million children die every year worldwide, and nearly 40% of the deaths occur in the neonatal period (https://www.who.int/news-room/fact-sheets/detail/newborns-reducing-mortality). Infections are among the most important causes of mortality in this age group. Prevention of infections in neonates is a priority, and understanding the etiopathogenesis of infections in this vulnerable period will pave the way towards improving outcomes.

Challenges in the treatment and prevention of neonatal infections include access to healthcare, availability of appropriate antibiotics, microbial antibiotic resistance (Methicillin Resistant Staphylococcus Aureus (MRSA), Vancomycin Resistant Enterococci (VRE) and multi-drug resistance in gram-negative organisms), and facilitating normal microbiome development. New antibiotics are needed, and non-antibiotic strategies for prevention of neonatal infections (e.g., lactoferrin, probiotics or other immunomodulatory agents) need to be explored.

We are inviting academics, researchers, and higher-degree students conducting research on infections and neonatal outcomes both in developing and developed countries to submit abstracts for consideration in a Special Issue of the International Journal of Environmental Research and Public Health.

We especially welcome multidisciplinary research in the area of neonatal infections in the following areas:

  • Epidemiology of neonatal infections in developed and developing countries;
  • Etiopathogenesis of specific neonatal infections and modes for prevention;
  • Evaluation of innovative therapeutic and prophylactic interventions against neonatal infections;
  • Neonatal microbiome perturbations which predispose to neonatal sepsis;
  • Immunonutrients and nutritional interventions to prevent infections;
  • Congenital and acquired immunodeficiency in the neonate that lead to neonatal infections;
  • Antimicrobial resistance and antibiotic stewardship;
  • Catheter-associated bloodstream infections and bundles to prevent them.

This Special Issue is open to any subject area related to addressing prevention and treatment of neonatal infections. The listed keywords suggest just a few of the many possibilities.

Prof. Dr. Mohan Pammi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Neonate
  • Sepsis
  • Infection
  • Prevention
  • Treatment
  • Antimicrobial resistance
  • Antimicrobial stewardship
  • Microbiome

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 870 KiB  
Article
Diagnosis of Neonatal Late-Onset Infection in Very Preterm Infant: Inter-Observer Agreement and International Classifications
by Gaelle Bury, Stéphanie Leroux, Cristhyne Leon Borrego, Christèle Gras Leguen, Delphine Mitanchez, Geraldine Gascoin, Aurore Thollot, Jean Michel Roué, Guy Carrault, Patrick Pladys and Alain Beuchée
Int. J. Environ. Res. Public Health 2021, 18(3), 882; https://doi.org/10.3390/ijerph18030882 - 20 Jan 2021
Cited by 6 | Viewed by 2004
Abstract
Background: The definition of late-onset bacterial sepsis (LOS) in very preterm infants is not unified. The objective was to assess the concordance of LOS diagnosis between experts in neonatal infection and international classifications and to evaluate the potential impact on heart rate variability [...] Read more.
Background: The definition of late-onset bacterial sepsis (LOS) in very preterm infants is not unified. The objective was to assess the concordance of LOS diagnosis between experts in neonatal infection and international classifications and to evaluate the potential impact on heart rate variability and rate of “bronchopulmonary dysplasia or death”. Methods: A retrospective (2017–2020) multicenter study including hospitalized infants born before 31 weeks of gestation with intention to treat at least 5-days with antibiotics was performed. LOS was classified as “certain or probable” or “doubtful” independently by five experts and according to four international classifications with concordance assessed by Fleiss’s kappa test. Results: LOS was suspected at seven days (IQR: 5–11) of life in 48 infants. Following expert classification, 36 of them (75%) were considered as “certain or probable” (kappa = 0.41). Following international classification, this number varied from 13 to 46 (kappa = −0.08). Using the expert classification, “bronchopulmonary dysplasia or death” occurred less frequently in the doubtful group (25% vs. 78%, p < 0.001). Differences existed in HRV changes between the two groups. Conclusion: The definition of LOS is not consensual with a low international and moderate inter-observer agreement. This affects the evaluation of associated organ dysfunction and prognosis. Full article
Show Figures

Figure 1

Back to TopTop