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  • Review
  • Open Access

Background/objectives: Metabolomics has emerged as a powerful systems-biology tool for deciphering dynamic metabolic alterations occurring during infectious diseases and following vaccination. While genomics and proteomics provide extensive molecular...

  • Article
  • Open Access
67 Views
12 Pages

Human Immunodeficiency Virus Infection in Romania Versus Europe: An Epidemiological and Public Health Perspective, 2024 Update

  • Andreea-Iuliana Ciobanu,
  • Sebastian Ionescu,
  • Ana Maria Tudor,
  • Mariana Mărdărescu,
  • Laurențiu-Mihăiță Stratan,
  • Adrian Gabriel Marinescu,
  • Cătălin Tiliscan,
  • Aida-Isabela Adamescu,
  • Oana Ganea and
  • Sorin Ștefan Aramă
  • + 1 author

Background/Objectives: This study presents a comprehensive and updated epidemiological and public health assessment of human immunodeficiency virus (HIV) in Romania during 2022–2024, situated within the wider European context. Methods: For this...

  • Article
  • Open Access
90 Views
14 Pages

Persistence of Symptoms and Long-Term Recovery in Hospitalized COVID-19 Patients: Results from a Five-Year Follow-Up Cohort

  • Ana Roel Conde,
  • Francisco Javier Membrillo de Novales,
  • María Navarro Téllez,
  • Carlos Gutiérrez Ortega and
  • Miriam Estébanez Muñoz

Background/Objectives: This study aimed to determine the prevalence of persistent symptoms and the radiological and laboratory evolution at 6 months and 5 years after discharge in patients hospitalized for SARS-CoV-2 pneumonia during the first wave o...

  • Essay
  • Open Access
116 Views
8 Pages

Faster than Virus: The Physics of Pandemic Prediction

  • Serena Vita,
  • Giovanni Morlino,
  • Alessandra D’Abramo,
  • Laura Scorzolini,
  • Gaetano Maffongelli,
  • Delia Goletti,
  • Francesco Vairo,
  • Enrico Girardi,
  • Massimo Ciccozzi and
  • Emanuele Nicastri

Background: Zoonotic spillover events with pandemic potential are increasingly associated with environmental change, ecosystem disruption, and intensified human–animal interactions. Although the specific origin and timing of future pandemics re...

  • Article
  • Open Access
164 Views
16 Pages

Beyond the Skin: Topical Amphotericin B Nanocarriers Targeting Cutaneous Leishmaniasis with Suppression of Lymphatic Parasite Burden

  • Francisco Alexandrino-Júnior,
  • Gabriel Barcellos,
  • Luiz Filipe Gonçalves-Oliveira,
  • Luzia Monteiro de Castro Côrtes,
  • Franklin Souza-Silva,
  • Carlos Roberto Alves,
  • Geovane Dias-Lopes,
  • Juliana Figueiredo Peixoto,
  • Beatriz Ferreira de Carvalho Patricio and
  • Helvécio Vinícius Antunes Rocha

Background/Objectives: Cutaneous leishmaniasis (CL) remains a global health challenge, with treatment options often limited by drug resistance and systemic toxicity. Amphotericin B (AmB) represents a promising alternative. but intravenous administrat...

  • Case Report
  • Open Access
170 Views
8 Pages

An Unusual Case of Listeria monocytogenes-Associated Rhombencephalitis Complicated by Brain Abscesses in Italy, 2024

  • Maria Gori,
  • Giorgia Orsani,
  • Carlotta Ortelli,
  • Erika Scaltriti,
  • Luca Bolzoni,
  • Luigi Vezzosi,
  • Silvia Bianchi,
  • Clara Fappani,
  • Daniela Colzani and
  • Antonella Amendola
  • + 4 authors

Background/Objectives: Listeria monocytogenes (Lm) is an extremely rare cause of brain abscesses, accounting for 1–10% of neurolisteriosis cases reported in the literature, associated with high mortality (approximately 23%). Data on diagnosis,...

  • Article
  • Open Access
216 Views
12 Pages

Background/Objectives: Infective endocarditis (IE) remains a severe and complex disease despite advances in diagnosis and treatment. The changing epidemiological profile, with an ageing population, has reshaped its presentation and management. This s...

  • Case Report
  • Open Access
193 Views
15 Pages

A Rare Case of Rhizomucor pusillus Infection in a 3-Year-Old Child with Acute Lymphoblastic Leukemia, Presenting with Lung and Brain Abscesses—Case Report

  • Yanko Pahnev,
  • Boryana Avramova,
  • Natalia Gabrovska,
  • Yolin Dontcheva,
  • Genoveva Tacheva,
  • Krasimir Minkin,
  • Hans Kreipe,
  • Nadezhda Yurukova,
  • Marin Penkov and
  • Nikola Kartulev
  • + 10 authors

Invasive Mucormycosis (IM) is an extremely rare infection with a high mortality rate, caused by a group of fungi classified as Mucorales moulds. Rhizomucor pusillus is a saprophitic, thermophilic, and angioinvasive microorganism that grows and lives...

  • Article
  • Open Access
319 Views
10 Pages

Background: Onychomycosis is a common nail infection primarily caused by Trichophyton rubrum, posing therapeutic challenges due to poor antifungal penetration and high recurrence rates. Conventional treatments include topical and systemic antifungals...

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Infect. Dis. Rep. - ISSN 2036-7449