Next Article in Journal
A New Era in the Control of Tuberculosis
Previous Article in Journal
Molecular Typing of Mycobacterium tuberculosis Strains: A Fundamental Tool for Tuberculosis Control and Elimination
 
 
Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
Review

Tuberculosis Biomarkers: From Diagnosis to Protection

1
Translational Research Unit, Department of Epidemiology and Preclinical Research, National Institute for Infectious Diseases, L. Spallanzani, Rome, Italy
2
Department of Infectious Diseases, Leiden University Medical Centre, The Netherlands
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2016, 8(2), 6568; https://doi.org/10.4081/idr.2016.6568
Received: 29 April 2016 / Revised: 29 April 2016 / Accepted: 29 April 2016 / Published: 24 June 2016
New approaches to control tuberculosis (TB) worldwide are needed. In particular, new tools for diagnosis and new biomarkers are required to evaluate both pathogen and host key elements of the response to infection. Non-sputum based diagnostic tests, biomarkers predictive of adequate responsiveness to treatment, and biomarkers of risk of developing active TB disease are major goals. Here, we review the current state of the field. Although reports on new candidate biomarkers are numerous, validation and independent confirmation are rare. Efforts are needed to reduce the gap between the exploratory up-stream identification of candidate biomarkers, and the validation of biomarkers against clear clinical endpoints in different populations. This will need a major commitment from both scientists and funding bodies.
Keywords: Tuberculosis; biomarkers Tuberculosis; biomarkers
MDPI and ACS Style

Goletti, D.; Petruccioli, E.; Joosten, S.A.; Ottenhoff, T.H.M. Tuberculosis Biomarkers: From Diagnosis to Protection. Infect. Dis. Rep. 2016, 8, 6568. https://doi.org/10.4081/idr.2016.6568

AMA Style

Goletti D, Petruccioli E, Joosten SA, Ottenhoff THM. Tuberculosis Biomarkers: From Diagnosis to Protection. Infectious Disease Reports. 2016; 8(2):6568. https://doi.org/10.4081/idr.2016.6568

Chicago/Turabian Style

Goletti, Delia, Elisa Petruccioli, Simone A. Joosten, and Tom H.M. Ottenhoff. 2016. "Tuberculosis Biomarkers: From Diagnosis to Protection" Infectious Disease Reports 8, no. 2: 6568. https://doi.org/10.4081/idr.2016.6568

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop