Automated Technology for Personalized Cancer Medicine: A Theme Issue in Honor of Prof. Dr. Thomas Grogan

A special issue of Hemato (ISSN 2673-6357).

Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 10349

Special Issue Editors


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Guest Editor
Department of Cellular Pathology, University College London, 21 University Street, London WC1E 6DE, UK
Interests: microscope-based techniques; immunohistochemistry; immunofluorescence; antibodies; biomarkers; hematological malignancies; solid tumors; immuno-oncopathology; tumor microenvironment; immunotherapy

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Guest Editor
Department of Diagnostic Innovation, Fondazione IRCCS Istituto Nazionale dei Tumori, Via Venezian 1, 20133 Milan, Italy
Interests: immunohistochemistry; in situ molecular techniques; brightfield in situ hybridization; virologic characterization; EBV; HHV8/KSHV; HPV; tumor microenvironment; Hodgkin’s lymphoma; HIV-associated lymphomas
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Special Issue Information

Dear Colleagues,

This honorary issue celebrates Prof. Thomas Grogan, Emeritus Professor of Pathology at the University of Arizona and founder of Ventana Medical Systems Inc.

Prof Grogan’s scientific work was of great relevance in actively contributing to the development of the WHO classification of tumours of the hemopoietic and lymphoma tissues and his innovations in automated immunohistochemistry technology, as well as pre-analytical tissue processing, allowed him to develop several patents. The impact of these methodologies showed the clinical importance of cancer pathology, as they ensure reliable test results for determining patients’ treatment options. These advances, recognised by pathologists and clinical oncologists, further contributed to elevating the scientific importance of pathology.

We dedicate this honorary Special Issue to Prof. Tom Grogan, entitled "Automated Technology for Personalized Cancer Medicine", highlighting his major professional contributions, including novel development in the fields of immunohistology, in situ hybridization and clinical biomarkers.

The Special Issue will also focus on the impact of automated technologies on diagnostic and molecular pathology, as well as the identification of novel cancer therapies.

Prof. Dr. Teresa Marafioti
Prof. Dr. Annunziata Gloghini
Guest Editors

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Keywords

  • personalized cancer medicine
  • cancer diagnosis
  • automated technology
  • lymphoma classification

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Published Papers (2 papers)

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Review

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24 pages, 1816 KiB  
Review
Diffuse Large B-Cell Lymphoma: Recognition of Markers for Targeted Therapy
by Laura Tomas-Roca, Marta Rodriguez, Ruth Alonso-Alonso, Socorro M. Rodriguez-Pinilla and Miguel Angel Piris
Hemato 2021, 2(2), 281-304; https://doi.org/10.3390/hemato2020017 - 14 May 2021
Cited by 1 | Viewed by 7119
Abstract
Diffuse large B-cell lymphomas (DLBCL)s, the most common type of Non-Hodgkin’s Lymphoma, constitute a heterogeneous group of disorders including different disease sites, strikingly diverse molecular features and a profound variability in the clinical behavior. Molecular studies and clinical trials have partially revealed the [...] Read more.
Diffuse large B-cell lymphomas (DLBCL)s, the most common type of Non-Hodgkin’s Lymphoma, constitute a heterogeneous group of disorders including different disease sites, strikingly diverse molecular features and a profound variability in the clinical behavior. Molecular studies and clinical trials have partially revealed the underlying causes for this variability and have made possible the recognition of some molecular variants susceptible of specific therapeutic approaches. The main histogenetic groups include the germinal center, activated B cells, thymic B cells and terminally differentiated B cells, a basic scheme where the large majority of DLBCL cases can be ascribed. The nodal/extranodal origin, specific mutational changes and microenvironment peculiarities provide additional layers of complexity. Here, we summarize the status of the knowledge and make some specific proposals for addressing the future development of targeted therapy for DLBC cases. Full article
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13 pages, 1362 KiB  
Commentary
On the Shoulders of a Giant: Contributions of Thomas Grogan, MD to Hematopathology
by Yasodha Natkunam and Roger A. Warnke
Hemato 2021, 2(1), 103-115; https://doi.org/10.3390/hemato2010006 - 28 Feb 2021
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Abstract
The story of Thomas Grogan, MD is one of the most compelling narratives in the modern history of pathology. Progressing from a quintessential academic pathologist to an entrepreneur and a renowned inventor, his remarkable journey is one of creativity, courage, and a keen [...] Read more.
The story of Thomas Grogan, MD is one of the most compelling narratives in the modern history of pathology. Progressing from a quintessential academic pathologist to an entrepreneur and a renowned inventor, his remarkable journey is one of creativity, courage, and a keen focus on improving the care of cancer patients. By enabling precision health and empowering the pathologist in that mission, he transformed the landscape of diagnostic pathology. In this review, we describe some of his salient contributions and how his vision has shaped and continues to shape hematopathology today. Full article
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