Yeast Applications in Gene Mutation

Dear Colleagues,

Yeast is an excellent model to investigate the molecular mechanisms and genetic control of mutations and, in general, chromosomal instability. Over the years, yeast has given a valuable contribution to our understanding biological relations between mutagenesis and cancer. Moreover, yeast-based functional assays have been developed to characterize cancer-associated mutations in several tumor-suppressor genes; “humanized” yeast strains have been constructed and validated in order to investigate the genetic control of fundamental biological processes and their association to human diseases. Therefore, yeast represents a very helpful tool to investigate DNA repair and mutagenesis pathways that are involved in gene mutation. Recently, as cutting-edge research, several high-throughput yeast screenings have been reported where up to several thousands of mutations have been generated and analyzed simultaneously. This Special Issue will present recent advances on genetic approaches in yeast to study and characterize gene mutations involved in biological processes and diseases. Research articles and reviews will be considered for publication in this Issue.

Dr. Alvaro Galli
Guest Editor

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