Special Issue "Advances in Single Molecule, Real-Time (SMRT) Sequencing"
Deadline for manuscript submissions: closed (31 January 2019) | Viewed by 67185
A printed edition of this Special Issue is available here.
Interests: next-generation sequencing; single-molecule sequencing; clinical sequencing; bioinformatics; genomics
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2. Department of Pediatrics, University of Cincinnati, 2600 Clifton Ave, Cincinnati, OH 45220, USA
Interests: next-generation sequencing; single-molecule sequencing; clinical sequencing; bioinformatics; 22q11 deletion syndrome
PacBio’s single molecule, real-time (SMRT) sequencing technology offers important advantages over the short-read DNA sequencing technologies that currently dominate the market. This includes exceptionally long read lengths (20 kb or more), unparalleled consensus accuracy, and the ability to sequence native, non-amplified DNA molecules. From microbes to vertebrates, long reads are now used to create highly accurate de novo genome assemblies, characterize complex structural variations, permit full-length RNA isoform sequencing, and directly phase variants. The high accuracy further enables low frequency mutation detection and clonal evolution determination. Besides reducing biases, sequencing native DNA also permits the direct measurement of DNA base modifications. Therefore, SMRT sequencing has become an attractive technology in many fields, such as agriculture, basic science, and medical research. The boundaries of SMRT sequencing are being continuously pushed by developments in bioinformatics and sample preparation.
This Special Issue is a collection of articles showcasing the latest developments and the breadth of applications enabled by SMRT sequencing technology.
Dr. Adam Ameur
Dr. Matthew S. Hestand
Manuscript Submission Information
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- SMRT sequencing
- genome assembly
- structural variation
- RNA isoforms
- DNA base modifications
- targeted sequencing
- clinical sequencing