Special Issue "Non-coding RNAs: Variety of Roles and Applications in Human Diseases"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".

Deadline for manuscript submissions: 31 December 2020.

Special Issue Editor

Prof. Keun Hur
E-Mail Website
Guest Editor
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea
Interests: Cancer, Metastasis, Biomarker, Non-coding RNAs, microRNA, lncRNA, Exosome

Special Issue Information

Dear Colleagues,

Non-coding RNAs (ncRNAs) are classified as microRNA (miRNA) (containing 19–25 nucleotides) and lncRNA (containing more than 200 nucleotides) according to their length. NcRNAs modulate gene expression at the post-transcriptional level by degradation or translational inhibition of target mRNAs. They are related to many biologic processes, such as development, cell differentiation, proliferation, apoptosis, and inflammation. In addition, ncRNAs are also known to be associated with the diagnosis, classification, progression, and prognosis of many human diseases. Therefore, they can be considered as potential biomarkers for disease diagnosis and as therapeutic targets.

In this Special Issue, we would like to invite submissions of original research articles and review articles focused on ncRNAs, in particular, on their functions, regulatory mechanisms, and applications. We also welcome studies that highlight new technologies, new analysis platforms, new animal models, and new manipulation tools for the study of all kinds of RNA.

Prof. Keun Hur
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Non-coding RNAs
  • Biomarker
  • microRNA
  • lncRNA
  • Exosome
  • Cancer
  • Inflammatory disease
  • Metabolic disease
  • Aging

Published Papers (1 paper)

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Research

Open AccessArticle
MicroRNA-1258 Inhibits the Proliferation and Migration of Human Colorectal Cancer Cells through Suppressing CKS1B Expression
Genes 2019, 10(11), 912; https://doi.org/10.3390/genes10110912 - 08 Nov 2019
Abstract
Increasing evidence has demonstrated that increased expression of cyclin-dependent kinase regulatory subunit 1B (CKS1B) is associated with the pathogenesis of many human cancers, including colorectal cancer (CRC). However, the regulatory mechanisms underlying the expression of CKS1B in CRC are not completely understood. Here, [...] Read more.
Increasing evidence has demonstrated that increased expression of cyclin-dependent kinase regulatory subunit 1B (CKS1B) is associated with the pathogenesis of many human cancers, including colorectal cancer (CRC). However, the regulatory mechanisms underlying the expression of CKS1B in CRC are not completely understood. Here, we investigate the role played by microRNAs in the expression of CKS1B and carcinogenesis in CRC. Among the six microRNAs predicted to target CKS1B gene expression, only miR-1258 was revealed to downregulate CKS1B expression through binding to its 3’-UTR region, as ectopic miR-1258 expression suppressed CKS1B expression and vice versa. In CRC, miR-1258 expression also decreased cell proliferation and migration in vitro and tumor growth in vivo, similar to cells with silenced CKS1B expression. Considering the highly increased levels of CKS1B and decreased expression of miR-1258 in tumors from CRC patients, these findings suggest that miR-1258 may play tumor-suppressive roles by targeting CKS1B expression in CRC. However, the therapeutic significance of these findings should be evaluated in clinical settings. Full article
(This article belongs to the Special Issue Non-coding RNAs: Variety of Roles and Applications in Human Diseases)
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