Epigenetic Mechanisms of Stem Cell Aging
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 10 January 2026 | Viewed by 18
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue seeks to explore the pivotal role of epigenetic mechanisms in regulating stem cell aging and their broader implications for tissue homeostasis and organismal aging. Stem cells are essential for tissue regeneration and repair, but their function declines with age. According to emerging evidence, this is linked to epigenetic alterations, including changes in DNA methylation, histone modifications, and chromatin structure. With the rapid advancement of next-generation epigenomic and transcriptomic technologies, it is now possible to analyze rare stem cell populations at a high level of detail. This Special Issue aims to garner cutting-edge research and reviews that investigate how age-associated epigenetic reprogramming influences stem cell identity, fate decisions, and regenerative potential and how such changes contribute to age-related tissue dysfunction and diseases. By shedding light on the molecular mechanisms underpinning stem cell aging, this collection hopes to inform therapeutic strategies that target epigenetic rejuvenation and delay or reverse age-associated tissue decline.
Dr. Romeo Blanc
Guest Editor
Manuscript Submission Information
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Keywords
- stem cell aging
- epigenetics
- DNA methylation
- histone modifications
- chromatin remodeling
- single-cell omics
- transcriptomics
- regenerative decline
- cell fate decisions
- tissue homeostasis
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