Genes | Invitation to Read the Editor’s Choice Articles in Q2 of 2025
Editor’s choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a napshot of some of the most exciting work published in the various research areas of the journal. You are welcome to read the updated 2025 Q2 articles, a curated list of high-quality articles from Genes (ISSN: 2073-4425).
A list of these papers is provided below:
1. “A Comprehensive Review of Deep Learning Applications with Multi-Omics Data in Cancer Research”
by Cesare Rollo, Corrado Pancotti, Flavio Sartori, Francesco Codicè, Giovanni Birolo, Isabella Caranzano and Piero Fariselli
Genes 2025, 16(6), 648; https://doi.org/10.3390/genes16060648
Full text available online: http://www.mdpi.com/2073-4425/16/6/648
2. “Impact of Heavy Metal and Resistance Genes on Antimicrobial Resistance: Ecological and Public Health Implications”
by Carlos G. Sánchez-Corona, Cecilia Hernández-Cortez, Graciela Castro-Escarpulli, Hugo G. Castelán-Sánchez, Jorge Rojas-Vargas and Luis Uriel Gonzalez-Avila
Genes 2025, 16(6), 625; https://doi.org/10.3390/genes16060625
Full text available online: http://www.mdpi.com/2073-4425/16/6/625
3. “MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A Review”
by Antoni F. Araszkiewicz, Bartłomiej Białecki, Danuta Januszkiewicz-Lewandowska, Krzysztof Jańczak, Michał Szczechowski, Paweł Wójcik and Szymon Kubiak
Genes 2025, 16(4), 441; https://doi.org/10.3390/genes16040441
Full text available online: http://www.mdpi.com/2073-4425/16/4/441
4. “The Dynamic Remodeling of Plant Cell Wall in Response to Heat Stress”
by Chengchen Lu, Jiarui Chen, Leiming Wu, Shijie Hu, Wenfei Li, Xiaomeng Feng and Yirui Tan
Genes 2025, 16(6), 628; https://doi.org/10.3390/genes16060628
Full text available online: http://www.mdpi.com/2073-4425/16/6/628
5. “Human CD36: Gene Regulation, Protein Function, and Its Role in Atherosclerosis Pathogenesis”
by Monika Rac
Genes 2025, 16(6), 705; https://doi.org/10.3390/genes16060705
Full text available online: http://www.mdpi.com/2073-4425/16/6/705
6. “Advancing Depression Management Through Biomarker Discovery with a Focus on Genetic and Epigenetic Aspects: A Comprehensive Study on Neurobiological, Neuroendocrine, Metabolic, and Inflammatory Pathways”
by Jelena Milic, Rosa Sapic and Sladjana Jovic
Genes 2025, 16(5), 487; https://doi.org/10.3390/genes16050487
Full text available online: http://www.mdpi.com/2073-4425/16/5/487
7. “The Role of Adiponectin and ADIPOQ Variation in Metabolic Syndrome: A Narrative Review”
by Joanna Michałowska, Justyna Dąbrowska, Paweł Bogdański and Wiktoria Błażejewska
Genes 2025, 16(6), 699; https://doi.org/10.3390/genes16060699
Full text available online: http://www.mdpi.com/2073-4425/16/6/699
8. “Updates on the Regulatory Framework of Edited Organisms in Brazil: A Molecular Revolution in Brazilian Agribusiness”
by Amanda M. M. Araújo, Elíbio L. Rech, Fabrício F. Costa, Gabriel da S. Medina, Giovanni R. Vianna, Gustavo R. Rodriguez, Jaim J. da Silva Junior, Júlio C. M. Rodrigues, Ludmila R. de Souza, Michel L. Leite et al.
Genes 2025, 16(5), 553; https://doi.org/10.3390/genes16050553
Full text available online: http://www.mdpi.com/2073-4425/16/5/553
9. “Y-STR Databases—Application in Sexual Crimes”
by António Amorim, Jennifer Fadoni, Laura Cainé and Rita Costa
Genes 2025, 16(5), 484; https://doi.org/10.3390/genes16050484
Full text available online: http://www.mdpi.com/2073-4425/16/5/484
10. “Analysis of Codon Usage Bias of 30 Chloroplast Genomes in Ulva (Ulvophyceae, Chlorophyta)”
by Hongni Liu, Jiao Fang, Liming Qin and Zhangfeng Hu
Genes 2025, 16(5), 608; https://doi.org/10.3390/genes16050608
Full text available online: http://www.mdpi.com/2073-4425/16/5/608
11. “A Review of the Diagnostic Approaches for the Detection of Antimicrobial Resistance, Including the Role of Biosensors in Detecting Carbapenem Resistance Genes”
by Evangelyn C. Alocilja and Kaily Kao
Genes 2025, 16(7), 794; https://doi.org/10.3390/genes16070794
Full text available online: http://www.mdpi.com/2073-4425/16/7/794
12. “Deciphering Gut Microbiome in Colorectal Cancer via Robust Learning Methods”
by Huiye Han, Stefano Mangiola, Wodan Ling, Ying Li and Youran Qi
Genes 2025, 16(4), 452; https://doi.org/10.3390/genes16040452
Full text available online: http://www.mdpi.com/2073-4425/16/4/452
13. “Autism Spectrum Disorder: Genetic Mechanisms and Inheritance Patterns”
by Antonia Sica, Barbara Lombardo, Chiara Sotira, Francesca Rufino, Ilaria La Monica, Lucio Pastore and Maria Rosaria Di Iorio
Genes 2025, 16(5), 478; https://doi.org/10.3390/genes16050478
Full text available online: http://www.mdpi.com/2073-4425/16/5/478
14. “Analysis of Kallikrein 6, Acetyl-α-Tubulin, and Aquaporin 1 and 2 Expression Patterns During Normal Human Nephrogenesis and in Congenital Anomalies of the Kidney and Urinary Tract (CAKUT)”
by Ivana Kuzmić Prusac, Ivona Gotovac, Katarina Vukojević, Marin Ogorevc, Mirna Saraga-Babić, Nela Kelam and Snježana Mardešić
Genes 2025, 16(5), 499; https://doi.org/10.3390/genes16050499
Full text available online: http://www.mdpi.com/2073-4425/16/5/499
15. “Epigenetic Regulation of Human Vascular Calcification”
by Lova Prasadareddy Kajuluri, Michael Christof, Rajeev Malhotra, Sujin Lee and Yugene Young Guo
Genes 2025, 16(5), 506; https://doi.org/10.3390/genes16050506
Full text available online: http://www.mdpi.com/2073-4425/16/5/506
16. “The Role of Artificial Intelligence in Identifying NF1 Gene Variants and Improving Diagnosis”
by Efstathios Rallis, Kleomenis Lotsaris, Theano Eirini Touma, Vasiliki Sofia Grech and Vassiliki Kefala
Genes 2025, 16(5), 560; https://doi.org/10.3390/genes16050560
Full text available online: http://www.mdpi.com/2073-4425/16/5/560
17. “Gene–Diet Interactions in Diabetes Mellitus: Current Insights and the Potential of Personalized Nutrition”
by Angeliki Kapellou, Dimitrios Miltiadis Vrachnos, Effie Salata, Sevastiani Papailia and Spiros Vittas
Genes 2025, 16(5), 578; https://doi.org/10.3390/genes16050578
Full text available online: http://www.mdpi.com/2073-4425/16/5/578
18. “Obesity and Heart Failure: Mechanistic Insights and the Regulatory Role of MicroRNAs”
by Basak Icli, Furkan Bestepe, George F. Ghanem, Parul Sahu, Robert M. Blanton and Sezan Vehbi
Genes 2025, 16(6), 647; https://doi.org/10.3390/genes16060647
Full text available online: http://www.mdpi.com/2073-4425/16/6/647
19. “Radiogenomics of Stereotactic Radiotherapy: Genetic Mechanisms Underlying Radiosensitivity, Resistance, and Immune Response”
by Ana-Marija Bukovica Petrc, Damir Vučinić, Felipe Couñago, Ivona Antončić, Maja Kolak Radojčić and Matea Lekić
Genes 2025, 16(7), 732; https://doi.org/10.3390/genes16070732
Full text available online: http://www.mdpi.com/2073-4425/16/7/732
20. “Management of MET-Driven Resistance to Osimertinib in EGFR-Mutant Non-Small Cell Lung Cancer”
by Antonio Passaro, Carla Corvaja, Elena Battaiotto, Ester Del Signore, Filippo de Marinis, Gianluca Spitaleri, Giuseppe Curigliano, Ilaria Attili, Pamela Trillo Aliaga and Panagiotis Agisilaos Angelopoulos
Genes 2025, 16(7), 772; https://doi.org/10.3390/genes16070772
Full text available online: http://www.mdpi.com/2073-4425/16/7/772
21. “Identification and Expression Analysis of CCCH Zinc Finger Family Genes in Oryza sativa”
by Chengfang Zhan, Dali Zeng, Hongkai Wu, Liangbo Fu, Linzhou Huang, Liping Dai, Long Yang, Shunyuan Li, Xueli Lu and Zhihan Wang
Genes 2025, 16(4), 429; https://doi.org/10.3390/genes16040429
Full text available online: http://www.mdpi.com/2073-4425/16/4/429
22. “GC Content in Nuclear-Encoded Genes and Effective Number of Codons (ENC) Are Positively Correlated in AT-Rich Species and Negatively Correlated in GC-Rich Species”
by Douglas M. Ruden
Genes 2025, 16(4), 432; https://doi.org/10.3390/genes16040432
Full text available online: http://www.mdpi.com/2073-4425/16/4/432
23. “The microRNA Pathway of Macroalgae: Its Similarities and Differences to the Plant and Animal microRNA Pathways”
by Alexandra H. Campbell, Andrew L. Eamens, Jessica Webb, Min Zhao, Nicholas A. Paul and Scott F. Cummins
Genes 2025, 16(4), 442; https://doi.org/10.3390/genes16040442
Full text available online: http://www.mdpi.com/2073-4425/16/4/442
24. “Genetic Features of Tumours Arising in the Context of Suspected Hereditary Cancer Syndromes with RAD50, RAD51C/D, and BRIP1 Germline Mutations, Results of NGS-Reanalysis of BRCA/MMR-Negative Families”
by Amaya Olaverri, Enrique Lastra, Lara Hernández, Lucia C. Mateo, Mar Infante, Marta Orozco, Mercedes Durán, Mónica Arranz-Ledo and Noemí Martínez
Genes 2025, 16(4), 458; https://doi.org/10.3390/genes16040458
Full text available online: http://www.mdpi.com/2073-4425/16/4/458
25. “Unravelling the Genotype of the Apical Variant of Hypertrophic Cardiomyopathy in a Swedish Cohort”
by Antheia Kissopoulou, Cecilia Gunnarsson, Eva Ingemarsdotter Fernlund, Henrik Green, Jan-Erik Karlsson and Rada Ellegård
Genes 2025, 16(5), 494; https://doi.org/10.3390/genes16050494
Full text available online: http://www.mdpi.com/2073-4425/16/5/494
26. “Comparative Mitochondrial Genomic and Phylogenetic Study of Eight Species of the Family Lonchodidae (Phasmatodea: Euphasmatodea)”
by Bin Zhang, Qianwen Zhang, Siyu Pang, Ting Luo, Xun Bian and Yanting Qin
Genes 2025, 16(5), 565; https://doi.org/10.3390/genes16050565
Full text available online: http://www.mdpi.com/2073-4425/16/5/565
27. “Olig1/2 Drive Astrocytic Glioblastoma Proliferation Through Transcriptional Co-Regulation of Various Cyclins”
by Feihong Yang, Jialin Li, Mengge Sun, Wenhui Zheng, Yu Tian, Zhuangzhi Zhang and Ziwu Wang
Genes 2025, 16(5), 573; https://doi.org/10.3390/genes16050573
Full text available online: http://www.mdpi.com/2073-4425/16/5/573
28. “Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy”
by Catherine Le Stunff and Pierre Bougnères
Genes 2025, 16(5), 590; https://doi.org/10.3390/genes16050590
Full text available online: http://www.mdpi.com/2073-4425/16/5/590
29. “Genetic Diversity and Metabolic Profile of Tibetan Medicinal Plant Saussurea obvallata”
by Hao Su, Ji De, Shengnan Zhang, Shiyan Wang and Sujuan Wang
Genes 2025, 16(5), 593; https://doi.org/10.3390/genes16050593
Full text available online: http://www.mdpi.com/2073-4425/16/5/593
30. “Signaling Pathways in Gliomas”
by Ludmiła Grzybowska-Szatkowska and Paulina Stachyra
Genes 2025, 16(5), 600; https://doi.org/10.3390/genes16050600
Full text available online: http://www.mdpi.com/2073-4425/16/5/600
31. “Comparative Genomic Analysis Across Multiple Species to Identify Candidate Genes Associated with Important Traits in Chickens”
by Cheng Chang, Fuyang Zhang, Hengcong Chen, Hui Zhang and Jiamei Zhou
Genes 2025, 16(6), 627; https://doi.org/10.3390/genes16060627
Full text available online: http://www.mdpi.com/2073-4425/16/6/627
32. “Examination of Runs of Homozygosity Distribution Patterns and Relevant Candidate Genes of Potential Economic Interest in Russian Goat Breeds Using Whole-Genome Sequencing”
by Alexandra S. Abdelmanova, Alexey N. Frolov, Anastasia D. Solovieva, Arsen V. Dotsev, Darren K. Griffin, Elena A. Gladyr, Igor V. Gusev, Maxim A. Vladimirov, Michael N. Romanov, Nadezhda A. Churbakova et al.
Genes 2025, 16(6), 631; https://doi.org/10.3390/genes16060631
Full text available online: http://www.mdpi.com/2073-4425/16/6/631
33. “Identification of Novel Genetic Loci Involved in Testis Traits of the Jiangxi Local Breed Based on GWAS Analyses”
by Bahareldin Ali Abdalla Gibril, Jiguo Xu, Jing-E Ma, Ke Huang, Xinwei Xiong, Yanping Wu and Zhangfeng Wang
Genes 2025, 16(6), 637; https://doi.org/10.3390/genes16060637
Full text available online: http://www.mdpi.com/2073-4425/16/6/637
34. “The Emergence of Artificial Intelligence-Guided Karyotyping: A Review and Reflection”
by Agshin F. Taghiyev, Julia Holmes and Lynne S. Rosenblum
Genes 2025, 16(6), 685; https://doi.org/10.3390/genes16060685
Full text available online: http://www.mdpi.com/2073-4425/16/6/685
35. “Dopaminergic Modulation of Conscientiousness: DRD2 rs1799732 and Personality Traits in Elite Mixed Martial Arts Athletes”
by Aleksandra Suchanecka, Anna Grzywacz, Jolanta Chmielowiec, Jolanta Masiak, Kinga Łosińska, Krzysztof Chmielowiec, Milena Lachowicz and Remigiusz Recław
Genes 2025, 16(6), 720; https://doi.org/10.3390/genes16060720
Full text available online: http://www.mdpi.com/2073-4425/16/6/720
36. “Genome-Wide Analysis of HIPP Gene Family in Maize Reveals Its Role in the Cadmium Stress Response”
by Chunyan Gao, Dan Luo, Jian Cai, Jiaxin Tian, Jinbo Hou, Kaili Yu, Youcheng Zhu, Yuxuan Zhu and Zhirui Zhang
Genes 2025, 16(7), 770; https://doi.org/10.3390/genes16070770
Full text available online: http://www.mdpi.com/2073-4425/16/7/770
37. “Genetics of Suicide”
by Alfredo Bellon, Anil Kalyoncu and Mostafa Khalil
Genes 2025, 16(4), 428; https://doi.org/10.3390/genes16040428
Full text available online: http://www.mdpi.com/2073-4425/16/4/428
38. “Whole-Genome Insights into the Genetic Basis of Conformation Traits in German Black Pied (DSN) Cattle”
by Amelie Mandel, Gudrun A. Brockmann, Monika Reißmann and Paula Korkuć
Genes 2025, 16(4), 445; https://doi.org/10.3390/genes16040445
Full text available online: http://www.mdpi.com/2073-4425/16/4/445
39. “Role of MicroRNAs in Acute Myeloid Leukemia”
by Agnieszka Pluta, Agnieszka Wierzbowska, Aleksandra Sałagacka-Kubiak, Aneta Wiśnik, Dariusz Jarych, Izabela Zawlik, Kinga Krawiec, Magdalena Czemerska, Natalia Potocka and Piotr Strzałka
Genes 2025, 16(4), 446; https://doi.org/10.3390/genes16040446
Full text available online: http://www.mdpi.com/2073-4425/16/4/446
40. “Population-Specific Differences in Pathogenic Variants of Genes Associated with Monogenic Parkinson’s Disease”
by Amanda Wei-Yin Lim, Claudia Gonzaga-Jauregui, Dennis Yeow, Jue-Sheng Ong, Kishore R. Kumar, Luis M. García-Marín, Miguel E. Rentería, Natalia S. Ogonowski and Victor Flores-Ocampo
Genes 2025, 16(4), 454; https://doi.org/10.3390/genes16040454
Full text available online: http://www.mdpi.com/2073-4425/16/4/454
41. “Genome-Wide Identification and Expression Pattern Analysis of SBP Gene Family in Neolamarckia cadamba”
by Changcao Peng, Chuqing Cai, Guichen Jian, Jianmei Long, Keying Li, Linhan Tang, Wenjun Wu and Ziming Lei
Genes 2025, 16(4), 460; https://doi.org/10.3390/genes16040460
Full text available online: http://www.mdpi.com/2073-4425/16/4/460
42. “The Solute Carrier Superfamily as Therapeutic Targets in Pancreatic Ductal Adenocarcinoma”
by Hyuk Soo Eun, Jaejeung Kim, Jong Seok Joo, Sang Yeon Cho, Woo Sun Rou and Yun Dam Ko
Genes 2025, 16(4), 463; https://doi.org/10.3390/genes16040463
Full text available online: http://www.mdpi.com/2073-4425/16/4/463
43. “Functional Equivalence of Insulin and IGF-1 in the In Vitro Culture of Chicken Primordial Germ Cells”
by Bichun Li, Guangzheng Liu, Guohong Chen, Jiuzhou Song, Jun Wu, Kai Jin, Qisheng Zuo, Wei Han, Xin Liu, Yingjie Niu et al.
Genes 2025, 16(5), 481; https://doi.org/10.3390/genes16050481
Full text available online: http://www.mdpi.com/2073-4425/16/5/481
44. “Interrelation of Oxidative Stress and Genetics in Pathophysiology of Obesity and Obesity-Related Conditions”
by Emina Čolak and Lepša Žorić
Genes 2025, 16(5), 489; https://doi.org/10.3390/genes16050489
Full text available online: http://www.mdpi.com/2073-4425/16/5/489
45. “Epitranscriptomic Role of m6A in Obesity-Associated Disorders and Cancer Metabolic Reprogramming”
by Simeng Gu, Sujun Yan, Weijing Wen, Zhe Mo and Zhijian Chen
Genes 2025, 16(5), 498; https://doi.org/10.3390/genes16050498
Full text available online: http://www.mdpi.com/2073-4425/16/5/498
46. “Single Amino Acid Supplementation in Inherited Metabolic Disorders: An Evidence-Based Review of Interventions”
by Carlo Dionisi Vici, Elvira Verduci, Marco Spada and Martina Tosi
Genes 2025, 16(5), 502; https://doi.org/10.3390/genes16050502
Full text available online: http://www.mdpi.com/2073-4425/16/5/502
47. “Genotoxicity in Unconventional Mammalian Models of Wild, Urban, and Agricultural Ecosystems: A Systematic Review Under the One Health Approach”
by Daniela Marisol Ferré, Mariela Nieves and Nora Bibiana M. Gorla
Genes 2025, 16(5), 525; https://doi.org/10.3390/genes16050525
Full text available online: http://www.mdpi.com/2073-4425/16/5/525
48. “Non-Invasive Preimplantation Genetic Testing”
by Carmen Rubio, Daniela N. Bakalova and Luis Navarro-Sánchez
Genes 2025, 16(5), 552; https://doi.org/10.3390/genes16050552
Full text available online: http://www.mdpi.com/2073-4425/16/5/552
49. “Natural Bioproducts with Epigenetic Properties for Treating Cardiovascular Disorders”
by Iván Carrera, Lola Corzo, Olaia Martínez-Iglesias, Ramón Cacabelos and Vinogran Naidoo
Genes 2025, 16(5), 566; https://doi.org/10.3390/genes16050566
Full text available online: http://www.mdpi.com/2073-4425/16/5/566
50. “Understanding Glycogen Storage Disease Type IX: A Systematic Review with Clinical Focus—Why It Is Not Benign and Requires Vigilance”
by Andrea Zanaroli, Egidio Candela, Federico Baronio, Giacomo Biasucci, Giulia Montanari, Marcello Lanari and Rita Ortolano
Genes 2025, 16(5), 584; https://doi.org/10.3390/genes16050584
Full text available online: http://www.mdpi.com/2073-4425/16/5/584