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Gels
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Polymeric Hydrogels for Biomedical Application (2nd Edition)
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Polymeric Hydrogels for Biomedical Application (2nd Edition)

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 3014

Special Issue Editors

Dr. Ion Cosmin Călina

E-Mail Website
Guest Editor
Electron Accelerators Laboratory, National Institute for Laser, Plasma and Radiation Physics, 409 Atomiștilor St., 077125 Măgurele, Romania
Interests: polymers; hydrogels; radiation; crosslinking; biocompatibility; biomaterials; wound dressing
Special Issues, Collections and Topics in MDPI journals
Dr. Muhammad Asim Raza

E-Mail Website
Guest Editor
School of Chemical Engineering, Yeungnam University, Gyeongbuk 38541, Republic of Korea
Interests: polymers; hydrogels; crosslinking; drug delivery; wound healing; tissue Engineering
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue aims to showcase the latest advancements in polymeric hydrogel research, focusing on synthesis, characterization, and multifaceted applications. By harnessing innovative synthesis techniques. The applications of polymeric hydrogels are wide-ranging and impactful. Biomedical applications include drug/gene delivery for precision therapy, wound healing/dressing, tissue engineering, and 3D-printed scaffolds for regenerative medicine.

This Special Issue invites original research articles, reviews, and perspectives that delve into the diverse aspects of polymeric hydrogels. Topics of interest include the following:

  • Novel synthesis strategies and design principles for polymeric hydrogels;
  • Advances in characterizing hydrogel structures and properties;
  • Responsive and functional hydrogels for various biomedical applications;
  • Industrial implementations and technological innovations utilizing polymeric hydrogels.

We welcome contributions that will not only deepen our understanding of polymeric hydrogels but also inspire novel applications across disciplines. This collection of work promises to foster collaboration, stimulate further research, and accelerate the translation of polymeric hydrogel research into real-world solutions.

Dr. Ion Cosmin Călina
Dr. Muhammad Asim Raza
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymers
  • hydrogels
  • crosslinking
  • radiation
  • biocompatibility
  • drug delivery
  • wound healing
  • tissue engineering

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Further information on MDPI's Special Issue policies can be found here.

Related Special Issue

Published Papers (2 papers)

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Research

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17 pages, 8259 KB  
Article
NMR/MRI Techniques to Characterize Alginate-Based Gel Rafts for the Treatment of Gastroesophageal Reflux Disease
by Ewelina Baran, Piotr Kulinowski, Marek Król and Przemysław Dorożyński
Gels 2025, 11(9), 749; https://doi.org/10.3390/gels11090749 - 17 Sep 2025
Cited by 1 | Viewed by 1636
Abstract
Gastroesophageal reflux disease (GERD) is associated with symptoms such as heartburn, resulting from gastric content reflux. Alginate-based raft-forming gel formulations represent a non-pharmacological strategy for GERD management by forming a floating gel barrier in the stomach. This study evaluated three commercial anti-reflux oral [...] Read more.
Gastroesophageal reflux disease (GERD) is associated with symptoms such as heartburn, resulting from gastric content reflux. Alginate-based raft-forming gel formulations represent a non-pharmacological strategy for GERD management by forming a floating gel barrier in the stomach. This study evaluated three commercial anti-reflux oral gel systems under simulated fed-state gastric conditions, using in vitro magnetic resonance relaxometry techniques. Magnetic resonance imaging (MRI) was performed in 0.01 M hydrochloric acid (HCl) to visualize gel raft formation, spatial structure, and spatial distribution of effective T2 relaxation time. Nuclear magnetic resonance (NMR) relaxometry in 0.01 M deuterium chloride (DCl) measured T1 and T2 relaxation times of the protons that were initially included in the preparation to assess its molecular mobility within the gel matrix. Two formulations formed floating, coherent gels, whereas the remaining one exhibited only polymer swelling without flotation. In one case, relaxometry data revealed a solid-like component that can be detected, indicating enhanced mechanical stability. The performance of each formulation was influenced by interactions among alginate, bicarbonates, and calcium ions, which determined gel consistency and flotation behavior. MRI and NMR relaxometry in vitro provide valuable non-invasive insights into the structural and functional behavior of alginate-based gel formulations. This approach supports the rational design of advanced gel-based therapies for GERD by linking molecular composition with in situ performance. Full article
(This article belongs to the Special Issue Polymeric Hydrogels for Biomedical Application (2nd Edition))
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Review

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26 pages, 2347 KB  
Review
Hydrogels for Bone Regeneration: Properties, Additives, Preclinical and Clinical Applications
by Nesya Graupe, Saliha Ahmad, Ahmad Zia, Michael Hadjiargyrou and Azhar Ilyas
Gels 2025, 11(11), 914; https://doi.org/10.3390/gels11110914 - 16 Nov 2025
Viewed by 1085
Abstract
Severe bone loss from trauma, fractures, tumor resections, and disease are devastating injuries that do not heal completely without external, and most of the time surgical, interventions. Although surgical interventions such as bone grafts and metal prostheses are commonly employed, these conventional approaches [...] Read more.
Severe bone loss from trauma, fractures, tumor resections, and disease are devastating injuries that do not heal completely without external, and most of the time surgical, interventions. Although surgical interventions such as bone grafts and metal prostheses are commonly employed, these conventional approaches present several limitations, including limited donors, risks of immune rejection and postoperative inflammation, and significant pain experienced by both donors and recipients. Hydrogels offer a promising alternative because of their controllable mechanical properties, biocompatibility, and structural resemblance to the extracellular matrix. In addition, hydrogels can be modified with substances such as growth factors, hormones, and drugs to facilitate accelerated bone repair. This review summarizes the recent advances in hydrogel development for bone repair, their structural design, biological functionality, and preclinical and clinical applications. Full article
(This article belongs to the Special Issue Polymeric Hydrogels for Biomedical Application (2nd Edition))
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