Advancing Green Chemistry in Hydrogel Development: Design, Synthesis, and Characterization

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Chemistry and Physics".

Deadline for manuscript submissions: 30 September 2025 | Viewed by 841

Special Issue Editors


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Guest Editor
Department of Drug Chemistry and Technologies, Faculty of Pharmacy and Medicine, "Sapienza" University of Rome, Rome, Italy
Interests: polysaccharide; hydrogels; nanohydrogels; drug delivery; tissue engineering
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Guest Editor
Department of Physical and Organic Chemistry, Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia
Interests: organic chemistry; catalysis; hydrogels; green chemistry

Special Issue Information

Dear Colleagues,

Recent studies have highlighted a growing interest in hydrogels. This is due to their remarkable properties, which include their high water content, porosity, and flexibility, rendering them highly promising in a variety of biomedical applications. These three-dimensional polymeric networks, either physically or chemically cross-linked, possess hydrophilic properties that enable them to absorb and retain water and biological fluids. These polymeric mixtures play a significant role in diverse applications such as wound healing, contact lenses, implant coating, drug delivery, tissue engineering, agriculture, bio-sensors, and various hygiene products. Choosing naturally derived cross-linking agents not only ensures the safety of biomedical applications but also contributes to both scientific and environmental goals for medical advancement. Consequently, in this Special Issue, we aim to collect studies on “Advancing Green Chemistry in Hydrogel Development: Design, Synthesis, and Characterization". We welcome investigations into synthesizing eco-friendly hydrogel compounds, particularly utilizing biodegradable and biocompatible materials.

Prof. Dr. Pietro Matricardi
Dr. Njomza Ajvazi
Guest Editors

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Keywords

  • hydrogels
  • biomolecules
  • natural polymers
  • biocompatibility
  • biodegradability
  • green chemistry

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Published Papers (1 paper)

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Research

12 pages, 2118 KiB  
Article
Natural Bletilla striata Polysaccharide-Based Hydrogels for Accelerating Hemostasis
by Hui-Fang Lin, Yue-Yue Wang, Feng-Zhen Liu, Zi-Wei Yang, Hao Cui, Si-Yu Hu, Feng-He Li and Pei Pan
Gels 2025, 11(1), 48; https://doi.org/10.3390/gels11010048 - 8 Jan 2025
Viewed by 379
Abstract
Most of the existing hydrogel dressings have inadequacies in mechanical performance, biological activities, compatibility, or versatility, which results in the development of rapid, green, and cost-effective approaches for hydrogels in biochemical and biomedical applications becoming a top-priority task. Herein, inspired by the inherent [...] Read more.
Most of the existing hydrogel dressings have inadequacies in mechanical performance, biological activities, compatibility, or versatility, which results in the development of rapid, green, and cost-effective approaches for hydrogels in biochemical and biomedical applications becoming a top-priority task. Herein, inspired by the inherent bioactivity, water retention properties, and biocompatibility of natural polysaccharide hydrogels, we have prepared self-healing gels. Using Bletilla striata polysaccharide (BSP), carboxymethyl chitosan (CMCS), and borax via borate ester linkages, we created hemostatic and self-healing Chinese herbal medicine hydrogels in varying concentrations (2.5%, 3.0%, and 4.0%). A rotational rheometer was used to describe the hydrogels’ shape and rheological characteristics. At all concentrations, it was found that the hydrogels’ elastic modulus (G′) consistently and significantly outperformed their viscous modulus (G″), suggesting a robust internal structure. All of the hydrogels had cell viability levels as high as 100% and hemolysis rates below 1%, indicating the hydrogels’ outstanding biocompatibility. Furthermore, the hydrogels demonstrated superior hemostatic qualities in an in vivo mouse tail amputation model, as well as in in vitro coagulation tests. The results show that the hydrogel possesses excellent self-healing properties, as well as a good biocompatibility and hemostatic performance, thus paving the way for the development of a potential hemostatic green hydrogel. Full article
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