Microbial Detoxification of Mycotoxins in Food

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Microbiology".

Deadline for manuscript submissions: 16 March 2026 | Viewed by 550

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Guest Editor
Nutrition and Food Science, Faculty of Veterinary Science, Complutense University of Madrid, 28040 Madrid, Spain
Interests: mycotoxins; biocontrol; proteomics; dry-cured meat products
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Special Issue Information

Dear Colleagues,

Mycotoxins, secondary metabolites produced by molds, are a significant hazard for both humans and animals due to their toxicity. To avoid their presence in various foodstuffs, the most common strategy is focused on preventing the growth of mold on food surfaces. However, this often involves the use of synthetic antifungals, which can compromise the sensory quality of certain foods, such as traditional cured meats and cheeses. To avoid synthetic antifungals, biocontrol agents are a promising alternative. The use of microorganisms against toxigenic molds could not only reduce mold growth but also the levels of mycotoxins through different modes of action such as microbial detoxification, the alteration of gene expression, etc. Microbial detoxification opens up new pathways for using bioactive compounds produced by microorganisms independent of the biocontrol agent’s presence. Recently, research has begun to explore strategies that can enhance the effectiveness of these biocontrol methods within the food matrix itself. This could lead to more sustainable and safer approaches to food preservation, ensuring food safety and quality.

Dr. Micaela Álvarez
Dr. María J. J. Andrade
Guest Editors

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Keywords

  • biocontrol
  • detoxification
  • bioactive compounds
  • volatiles
  • food
  • mycotoxin degradation

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Published Papers (1 paper)

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Research

21 pages, 1632 KB  
Article
Mycotoxin Removal and Transcriptional Response of Pichia fermentans KCB21_L2
by Carolina Gómez-Albarrán, Silvia Rodríguez-Pires, Alba Sáez-Matía, Carlos Luz, Belén Patiño and Jéssica Gil-Serna
Foods 2025, 14(24), 4181; https://doi.org/10.3390/foods14244181 - 5 Dec 2025
Viewed by 272
Abstract
The presence of mycotoxins in food poses a significant risk to food safety, and it is essential to develop effective and safe detoxification strategies. In this study, we demonstrate the strong ability of Pichia fermentans KCB21_L2, a yeast isolated from kefir, to eliminate [...] Read more.
The presence of mycotoxins in food poses a significant risk to food safety, and it is essential to develop effective and safe detoxification strategies. In this study, we demonstrate the strong ability of Pichia fermentans KCB21_L2, a yeast isolated from kefir, to eliminate aflatoxin B1, fumonisin B1 and ocratoxin A. Viable cells removed aflatoxin B1 and fumonisin B1 more efficiently than heat-inactivated cells, particularly at pH values of 5.5 and 7.0, suggesting the involvement of an active removal process. Subsequently, we evaluated the capacity of P. fermentans KCB21_L2 to remove mycotoxins at high concentrations and investigated the underlying molecular and cellular responses. The yeast effectively eliminated high levels of all three mycotoxins. Transcriptional analysis revealed the activation of metabolic pathways related to amino acid catabolism and fatty acid metabolism, likely reflecting an adaptive stress response. However, no significant upregulation of specific genes related to mycotoxin-degrading enzymes was observed. In conclusion, the reduction process may involve multiple factors, including stress response pathways, possible production of organic acids, adsorption of mycotoxins into the cell wall, and constitutively expressed enzymes capable of degrading mycotoxins. In general, these findings highlight the multifactorial nature of yeast-mediated mycotoxin removal and establish P. fermentans KCB21_L2 as a promising candidate for safe biological decontamination in food systems. Full article
(This article belongs to the Special Issue Microbial Detoxification of Mycotoxins in Food)
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