New Insights into Sources of Nutrients and Bioactive Compounds in Foods—2nd Edition

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 1543

Special Issue Editors


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Guest Editor
1. Department of Food Technology of Plant Origin, Poznań University of Life Sciences, 60-624 Poznań, Poland
2. Collegium Medicum, Andrzej Frycz Modrzewski Krakow University, Kraków, Poland
Interests: bioactive compounds; medicinal plants; antioxidants; edible insects; functional food; plant-based food additives; waste management in food system; plant-based meat analogues; biopolymers
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Guest Editor
Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, 4 Berdychowo St., 60-965 Poznań, Poland
Interests: LC-MS/MS; ITP; solid phase extraction; liquid–liquid extraction; non-ionic surfactant; selenium speciation; pharmaceutical residues
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Chemistry and Technical Electrochemistry, Poznan University of Technology, 4 Berdychowo St., 60-965 Poznań, Poland
Interests: thermogravimetric analysis; scanning electron microscopy; FT-IR spectroscopy; X-ray diffraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Given the great success of the first volume of the Special Issue “New Insights into Sources of Nutrients and Bioactive Compounds in Foods” and the academic relevance of this topic, the journal Foods welcomes a second volume and invites authors to submit their new research to this Special Issue.

The agri-food industry generates huge amounts of waste every day, which is a serious problem for the environment. Therefore, the slogan "from waste to resources" has been promoted to reintroduce food waste into the economy as new raw materials—not only as nutrients, but also, above all, as compounds with targeted biological activity that can be used in the production of foods, including functional food. In this Special Issue of Foods, we would like to provide up-to-date information regarding novel and important achievements and the main challenges related to the isolation, characterization and uses of bioactive compounds in food science and technology.

Considering the abovementioned global circumstances, we would like to encourage leading scientists working on the topics of bioactive food, as well as those studying the biological activities of novel food ingredients, to submit original research or review papers. In particular, we invite original research papers and reviews that address any aspect of the use of novel bioactive compounds for food production and human nutrition. Papers on the study of medicinal plant bioactivity are also welcome.

Dr. Przemysław Kowalczewski
Dr. Joanna Zembrzuska
Dr. Paweł Jezowski
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • alternative sources of nutrients
  • antioxidants
  • bioactive peptides
  • biotechnological and nanotechnological methods in food technology
  • isolation and characterization of bioactive compounds
  • medicinal plants
  • naturally derived active ingredients
  • novel raw materials for food production
  • phenolic compounds
  • waste and by-product valorization

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Published Papers (3 papers)

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Research

23 pages, 1566 KB  
Article
Effects of the Brazilian Native Fruit Jaboticaba (Plinia cauliflora) Peel on Inflammatory and Oxidative Stress Pathways: Insights from a Pilot Study in Hemodialysis Patients and Renal Cell Models
by Ligia Soares Lima, Jessyca Sousa de Brito, Marcelo Ribeiro-Alves, Karen Salve Coutinho-Wolino, Rodrigo dos Santos P. Duarte, Rafael Hospodar Felippe Valverde, Marcelo Einicker-Lamas, Andresa A. Berretta, Carmen Lucía Sanz, Lia S. Nakao, Peter Stenvinkel and Denise Mafra
Foods 2025, 14(23), 4030; https://doi.org/10.3390/foods14234030 - 24 Nov 2025
Viewed by 383
Abstract
Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory and oxidative stress markers and uremic toxins among patients with chronic kidney [...] Read more.
Jaboticaba (Plinia cauliflora), a Brazilian native fruit rich in bioactive compounds, exhibits potent anti-inflammatory and antioxidant properties. This pilot study evaluated the effects of jaboticaba peel supplementation on inflammatory and oxidative stress markers and uremic toxins among patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and explored its molecular effects in LLC-PK1 renal cells. A randomized, controlled clinical trial was conducted with 27 patients (55.0 [19.5] years, BMI 24.3 [3.8] kg/m2) on regular HD. Participants were allocated to receive the jaboticaba peel formulation (3.3 g/day, equivalent to ~667 mg of phenolic compounds) for 3 weeks or to routine treatment (control). Plasma levels of interleukin (IL)-1β and IL-17E (ELISA), lipid peroxidation (TBARS), protein carbonylation, and plasma levels of uremic were analyzed. LLC-PK1 cells were treated with 100 µL of jaboticaba peel formulation at different concentrations, and a panel of inflammatory genes was evaluated. While plasma IL-1β and IL-17E concentrations were increased in the control group, the jaboticaba group exhibited no significant changes, suggesting anti-inflammatory protection. Transcriptomic analysis revealed downregulation of key components of the TLR–MYD88–NF-κB–IL-1 axis after cell treatment. Additionally, cells treated with jaboticaba formulation (1.5%) showed reduced ROS levels, indicating antioxidant capacity. In conclusion, supplementation with jaboticaba peel attenuated the increase in pro-inflammatory markers in HD patients. These results suggest that jaboticaba peel holds promise as an adjuvant nutritional intervention for chronic inflammation in CKD. Full article
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14 pages, 4325 KB  
Article
Phenolic Antioxidants in the Adriatic Halophyte Limbarda crithmoides: Variation Across Phenological Stages
by Petra Brzović, Sanja Radman and Ivana Generalić Mekinić
Foods 2025, 14(21), 3718; https://doi.org/10.3390/foods14213718 - 30 Oct 2025
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Abstract
Golden samphire [Limbarda crithmodes (L.) Dumort], a perennial, edible Mediterranean halophytic specie, is recognised for its richness in biologically active compounds and its associated health benefits. Despite its potential, it remains largely underexplored in Croatia. This study investigates the effect of plant’s [...] Read more.
Golden samphire [Limbarda crithmodes (L.) Dumort], a perennial, edible Mediterranean halophytic specie, is recognised for its richness in biologically active compounds and its associated health benefits. Despite its potential, it remains largely underexplored in Croatia. This study investigates the effect of plant’s phenological stage—vegetative phase (June), pre-flowering (July), and full flowering (August)—on its phenolic profile (total phenolics, flavonoids, and tannins using spectrophotometry, and individual phenolic compounds using ultra-high performance liquid chromatography and antioxidant potential (using three complementary in vitro assays)). Total phenolics, flavonoids and related antioxidant activity progressively increased from June to August. Among the 18 identified phenolic compounds, chlorogenic acid was the most abundant (355 to 455 µg/g), reaching its highest concentration in the August sample, while among flavonoids it was quercetin (32 to 34 µg/g). These findings suggest that golden samphire collected in the late summer flowering stage exhibits the highest phenolic and antioxidant potential, and that chlorogenic acid, likely acting in synergy with other phenolics, may play the key role in the plant’s biological activity, reinforcing its potential for future applications. Full article
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21 pages, 2583 KB  
Article
Soil Amendment with Poultry Manure, Biochar, and Coenzyme A Enhances Yield and Nutritional Composition of Moringa oleifera Lam.
by Baba Mamudu, Cristina García-Viguera, Diego A. Moreno, Eli Gaveh, Francis Appiah, Irene Idun, Sonia Medina and Raúl Domínguez-Perles
Foods 2025, 14(20), 3527; https://doi.org/10.3390/foods14203527 - 16 Oct 2025
Viewed by 581
Abstract
This study assessed the combined application of poultry manure (Pm), biochar (B), and coenzyme A (CoA) into soils to enhance Moringa oleifera Lam. growth, biomass yield, and nutritional and phytochemical composition. This approach allowed us to cover the gap of knowledge on sustainable, [...] Read more.
This study assessed the combined application of poultry manure (Pm), biochar (B), and coenzyme A (CoA) into soils to enhance Moringa oleifera Lam. growth, biomass yield, and nutritional and phytochemical composition. This approach allowed us to cover the gap of knowledge on sustainable, low-cost agronomic management alternatives suitable for smallholder systems. To achieve this objective a field experiment was conducted using three treatments (control (no amendment), Pm + B, and Pm + B + CoA) and four consecutive harvests were monitored. Morphological traits (height, stem diameter, number of branches, and leaf yield) were recorded, and phytochemical analyses of glucosinolates and (poly)phenols were performed via HPLC-DAD-ESI/MSn. Mineral and trace elements were quantified by ICP-OES. The main results retrieved allowed describing the capacity of the combined use of Pm + B + CoA to enhance plant growth and productivity, thus increasing the moringa trees’ height of 226.3 by 39.5%, on average, relative to control plants. ILeaf yield and branch number augmented up to 7.0-fold and 2.5-fold, respectively, under amendment treatments. Petiole girth also increased significantly by >50% (p < 0.01). Phytochemically, Pm + B + CoA significantly elevated total phenolics, vicenin-2, and quercetin acetyl-hexoside in leaves by 2.8-fold, on average, relative to control. The glucosinolate content also augmented as a result of the soil amendments assayed by 51.0%, on average, in stems and petioles, under Pm + B + CoA, compared to control samples. From these results, it can be concluded that the combined use of poultry manure, biochar, and CoA significantly improved M. oleifera growth, biomass yield, and nutritional quality, with a particular efficiency concerning (poly)phenolic accumulation. This low-cost, sustainable amendment strategy provides a viable agronomic solution in regions suffering socioeconomic constraints that hinder access to high-cost agronomic management options. Therefore, this approach effectively links ecological soil management with improved productivity, nutritional value, and potential for food industries. Full article
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