Food-Derived Bioactive Peptides: Correlation between Structure and Functional Properties

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 2263

Special Issue Editors


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Guest Editor
REQUIMTE/LAQV, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: bioactive peptides; novel foods; food allergens; food analysis; food chemistry; alternative peptide sources

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Guest Editor
REQUIMTE/LAQV, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: real-time PCR; species identification; PCR detection; DNA barcode; food adulteration; food authentication; food allergens; food science technology and engineering; food safety; food chemistry; GMO detection; DNA analysis; bioactive peptides; novel foods
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: food safety; bioactive compounds; allergenic proteins; food allergens; food chemistry; peptide immunomodulation.
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Faculty of Pharmacy, University of Porto, Porto, Portugal
Interests: bioactive peptides; novel foods; food allergens; food analysis; food chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Food is not only a source of nutrients, but also of bioactive compounds that have beneficial effects on human health. Among them, bioactive peptides are protein fragments typically between 2 and 20 amino acid residues in length with a molecular mass of 0.4–2 kDa. Depending on their molecular mass, number and type of amino acids present, net charge, bulkiness, and polarity, several bioactive properties can be attributed to them.

Small peptides can be derived from food processing, produced in the gastrointestinal tract during digestion, or isolated and used as dietary supplements. However, to exert their intended biological effects, they must reach their respective targets. This involves resisting the effects of intestinal brush border enzymes, reaching the bloodstream, and binding to the enzymes, whose activity is to be influenced. To date, peptides with diverse bioactivities have been identified, including antioxidant, antihypertensive, anti-diabetic, anti-obesity, anti-inflammatory, hypocholesterolemic, antimicrobial, anti-SARS-CoV-2, antithrombotic, and immunomodulatory bioactivities. Such properties have been identified in a wide range of food sources by in silico, in vitro, and in vivo assays, though the latter are still lacking.

In the era of by-product valorisation of the food industry, the identification of new sources of bioactive peptides can add value to these products and reduce their environmental impact in line with sustainability.

This Special Issue intends to bring momentum to the most outstanding research currently being conducted in this field, thereby stimulating further investigation and dissemination of new findings.

Dr. Carla Sílvia Silva Teixeira
Dr. Isabel Mafra
Dr. Joana Costa
Dr. Caterina Villa
Guest Editors

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Keywords

  • bioactive peptides
  • peptide novel sources
  • bioprospection
  • human health
  • nutraceutical
  • food processing
  • gastrointestinal digestion
  • bioactivities 
  • human nutrition
  • in silico analysis

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Published Papers (1 paper)

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Research

12 pages, 1349 KiB  
Article
Uncovering the Potential Somatic Angiotensin-Converting Enzyme (sACE) Inhibitory Capacity of Peptides from Acheta domesticus: Insights from In Vitro Gastrointestinal Digestion
by Carla S. S. Teixeira, Bruno Carriço-Sá, Caterina Villa, Joana Costa, Isabel Mafra, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria and Tânia G. Tavares
Foods 2024, 13(21), 3462; https://doi.org/10.3390/foods13213462 - 29 Oct 2024
Cited by 1 | Viewed by 888
Abstract
Entomophagy is being proposed as a sustainable and nutritious alternative protein source. Additionally, insect consumption is also associated with some health benefits mediated by bioactive compounds produced during gastrointestinal (GI) digestion. The antihypertensive property resulting from the inhibition of the somatic angiotensin-converting enzyme [...] Read more.
Entomophagy is being proposed as a sustainable and nutritious alternative protein source. Additionally, insect consumption is also associated with some health benefits mediated by bioactive compounds produced during gastrointestinal (GI) digestion. The antihypertensive property resulting from the inhibition of the somatic angiotensin-converting enzyme (sACE) by small peptides is one of the most common bioactivities related to insect consumption. This study aimed to investigate the potential sACE-inhibitory capacity of six peptides (AVQPCF, CAIAW, IIIGW, QIVW, PIVCF, and DVW), previously identified by the in silico GI digestion of Acheta domesticus proteins, validate their formation after in vitro GI digestion of A. domesticus by LC-MS/MS, and assess the bioactivity of the bioaccessible digesta. The results showed that the IC50 values of AVQPCF, PIVCF, and CAIAW on sACE were 3.69 ± 0.25, 4.63 ± 0.16, and 6.55 ± 0.52 μM, respectively. The obtained digesta demonstrated a sACE-inhibitory capacity of 77.1 ± 11.8 µg protein/mL extract (IC50). This is the first report of the sACE-inhibitory capacity attributed to whole A. domesticus subjected to GI digestion without any pre-treatment or protein concentration. This evidence highlights the potential antihypertensive effect of both the digesta and the identified peptides. Full article
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