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Foods
Special Issues
Milk Bioactive Compounds and Gut Microbiota Modulation
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Milk Bioactive Compounds and Gut Microbiota Modulation

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Dairy".

Deadline for manuscript submissions: 25 February 2026 | Viewed by 277

Special Issue Editors

Prof. Dr. Guangqing Mu

E-Mail Website
Guest Editor
Dalian Probiotics Function Research Key Laboratory, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China
Interests: development of functional probiotic resources; the interaction effect of bioactive substances in milk protein; methods and means for detecting milk components; probiotics regulate the health of the body by their effects on the intestinal flora; research on the Interaction mechanism of intestinal microbiota
Prof. Dr. Bo Yang

E-Mail Website
Guest Editor
State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Interests: probiotics; gut microbiome; gut health; immune diseases; metabolic syndrome; bacterial functional metabolites
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue of Foods is dedicated to reporting on the functionality and mechanisms of bioactive components in milk and probiotics, exploring the interaction effects among these bioactive components and their potential health benefits in regulating immunity, metabolism, and other aspects. It focuses on the functional mechanisms of probiotics in maintaining intestinal barriers, improving inflammatory states, and promoting nutrient absorption through the modulation of gut microbiota, revealing their roles in intestinal microecological regulation. Additionally, the journal emphasizes high-throughput detection methods and advanced technologies for assessing components such as proteins, peptides, and carbohydrates in dairy products, driving precision research in dairy science. By integrating multidisciplinary research findings, it provides theoretical support and a technical foundation for the development of functional dairy products and nutritional intervention strategies.

Prof. Dr. Guangqing Mu
Prof. Dr. Bo Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • probiotics
  • milk protein bioactive compounds
  • gut microbiota
  • intestinal health regulation
  • analytical methods for dairy components
  • fermented dairy products
  • metabolomics
  • nutritional intervention

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Published Papers (1 paper)

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Research

15 pages, 18510 KB  
Article
Bovine β-Casein Peptide YPFPGPIH Regulates Inflammation and Macrophage Activity via TLR/NF-κB/MAPK Signaling
by Junpeng Zhang, Xinyu Zhang, Guangqing Mu, Xiaomeng Wu and Jianping Wu
Foods 2025, 14(20), 3572; https://doi.org/10.3390/foods14203572 - 20 Oct 2025
Abstract
Food-derived bioactive peptides are known to possess immunomodulatory properties, although their molecular mechanisms remain incompletely characterized. In this study, we investigated the immunoregulatory effects and underlying mechanisms of YPFPGPIH, a peptide derived from bovine β-casein, using the RAW264.7 macrophage model. Our results demonstrate [...] Read more.
Food-derived bioactive peptides are known to possess immunomodulatory properties, although their molecular mechanisms remain incompletely characterized. In this study, we investigated the immunoregulatory effects and underlying mechanisms of YPFPGPIH, a peptide derived from bovine β-casein, using the RAW264.7 macrophage model. Our results demonstrate that YPFPGPIH enhanced macrophage proliferation and phagocytosis in a dose-dependent manner and promoted chemotactic migration through the upregulation of monocyte chemoattractant proteins MCP-1 and MCP-3. Under lipopolysaccharide (LPS)-induced inflammatory conditions, YPFPGPIH significantly reduced the levels of pro-inflammatory mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and nitric oxide (NO), while increasing the production of the anti-inflammatory cytokine interleukin-10 (IL-10), thereby reestablishing cytokine balance. Mechanistic studies revealed that YPFPGPIH inhibited LPS-induced activation of the NF-κB and MAPK pathways, as indicated by reduced nuclear translocation of p65 and decreased phosphorylation of ERK, JNK, and p38. Molecular docking analysis indicated strong binding affinities between YPFPGPIH and Toll-like receptors TLR2 and TLR4, suggesting the involvement of TLR-mediated signaling. Notably, YPFPGPIH downregulated inducible nitric oxide synthase (iNOS) expression and upregulated chemokine mRNA levels, reflecting its dual role in modulating inflammatory and migratory responses. These findings highlight YPFPGPIH as a multifunctional immunomodulatory peptide that fine-tunes macrophage activity through crosstalk between TLR, NF-κB, and MAPK signaling pathways. This study provides new insights for developing peptide-based therapeutics and functional foods aimed at managing inflammatory diseases. Full article
(This article belongs to the Special Issue Milk Bioactive Compounds and Gut Microbiota Modulation)
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