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Special Issue "Biocatalysis and Fermentation—Enzyme Production and Whole Cell Biocatalysis"
A special issue of Fermentation (ISSN 2311-5637).
Deadline for manuscript submissions: closed (30 November 2019).
Biocatalysis offers significant opportunities. Enzymes catalyse a vast range of chemical reactions, often with exquisite regio- and stereo-selectivity. They often do so at faster rates than traditional chemical catalysts and at lower temperatures and pressures. Enzymes typically operate in aqueous solution and are naturally biodegradable. Their potential for exploitation in “green chemistry” is substantial. The production of enzymes for biocatalysis typically requires the expression of the protein in a recombinant host, often bacteria or yeasts. Optimisation of fermentation conditions can result in significant advantages through the improvement of yield, quality and purity of the enzyme. Site-directed mutagenesis methods can be applied to engineer enzymes for altered specificity or improved stability. Alternatively, whole cells can be used as reaction vessels to synthesise particular chemicals. Often this requires engineering of the metabolic pathways present in the cells to redirect biosynthesis towards the desired product. Again, optimisation of the growth conditions is likely to be necessary to maximise yield. This Special Issue focuses on the use of microbial cells for the production of biocatalysts and in whole cell biocatalysis. Papers describing the optimisation of the production of enzymes and the operation of whole cell biocatalysis are encouraged as are papers describing theoretical approaches which can be applied to yield improvement.
Prof. David J. Timson
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- recombinant enzyme
- whole cell biocatalysis
- protein overexpression
- enzyme engineering
- metabolic pathway engineering
- green chemistry
- enzyme biotechnology
- yield improvement