Special Issue "Epigenetics of the Nervous System 2.0"

A special issue of Epigenomes (ISSN 2075-4655).

Deadline for manuscript submissions: closed (30 September 2019).

Special Issue Editors

Prof. Dr. Che-Kun James Shen
E-Mail Website
Guest Editor
Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
Interests: gene regulation, chromatin, DNA methylation, neurofunction, transcription
Special Issues and Collections in MDPI journals
Prof. Dr. Guoping Fan
E-Mail Website
Guest Editor
Department of Human Genetics David Geffen School of Medicine Gonda BLDG Rm. 6554 P.O.Box 957088 University of California Los Angeles Los Angeles, CA90095-7088, USA
Interests: epigenetics, gene expression, DNA methylation, neural stem cell differentiation, adult brain function, and somatic cell reprogramming
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

In the last few years, epigenetic modifications in the nervous system have proven to be fundamental for the correct development and function of the brain. It is well known that DNA methylation is associated with learning as well as with the development of several neurological disorders including neurodegeneration.

This Special Issue will be focused on the epigenetic changes that take place in the nervous system, from adolescent development through adulthood. In addition to invited reviews, we welcome research and/or methods manuscripts of exceptional interest on the following topics:

  • Effect of epigenetic changes in neural stem cells
  • Epigenetics and neuropathology
  • Animal models for the study of the relationship between epigenetics and the nervous system
  • Human neural pathologies and epigenetics

Prof. Dr. Che-Kun James Shen
Prof. Dr. Guoping Fan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessBrief Report
Global DNA Methylation in the Limbic System of Cattle
Epigenomes 2019, 3(2), 8; https://doi.org/10.3390/epigenomes3020008 - 05 May 2019
Abstract
To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers. Global DNA methylation was measured in [...] Read more.
To elucidate the extent to which DNA methylation varies across multiple tissues in the brain and between animals, we have quantified global DNA methylation in tissues comprising the limbic system for six Red Angus x Simmental steers. Global DNA methylation was measured in nine regions of the bovine brain: amygdala, the bed nucleus of the stria terminalis, cingulate gyrus, dorsal raphe, hippocampus, hypothalamus, nucleus accumbens, periaqueductal gray and prefrontal cortex. DNA methylation varies among animals for each tissue type and varies among tissue types for each animal. The highest amounts of DNA methylation were found in the amygdala, cingulate gyrus and dorsal raphe, while the bed nucleus of the stria terminalis, nucleus accumbens and periaqueductal gray had the lowest amounts of DNA methylation. A heatmap sorted by k-means clustering was generated to graphically display percent DNA methylation in relation to tissue type and animal number. This is the first study to report measures of DNA methylation in the limbic system of the bovine brain and can be used to inform the cattle genomics community of expected variation in cattle brain methylation. Full article
(This article belongs to the Special Issue Epigenetics of the Nervous System 2.0)
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