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Epigenomes
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Epigenetics of Neurobiology and Brain Diseases
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Epigenetics of Neurobiology and Brain Diseases

A special issue of Epigenomes (ISSN 2075-4655).

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5019

Special Issue Editor

Prof. Dr. Chunyu Liu

E-Mail Website
Guest Editor
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Interests: psychiatric genetics; regulatory networks in genomics; epigenomics; proteomics of postmortem brains

Special Issue Information

Dear Colleagues,

This Special Issue entitled "Epigenetics of Neurobiology and Brain Diseases" aims to present recent research on any aspect of the epigenetic studies of brain cells, neurological diseases, and psychiatric disorders. Epigenetics includes studies of DNA methylation, histone modification, RNA methylation, and other epigenetic features. Omics-based study is preferred. The study of candidate genes can be considered when strong justification is made.

Some of its focal points include, but are not limited to, the following:

  1. Epigenetic profiles and reference maps of brain tissues or cells;
  2. Changes in epigenetic markers in brain diseases;
  3. Epigenetic changes associated with environmental insults related to brain diseases;
  4. Epigenetic changes associated with clinical measures or treatment of brain diseases;
  5. Integration of genetics and epigenetics for brain diseases;
  6. Gene expression regulated by epigenetic features in the brain, brain cell, or neural cell models;
  7. Genetic regulation of epigenetic features in brain, brain cell, or neural cell models;
  8. Functional study of an epigenetic biomarker, and/or its genetic regulators.

Reviews, original research, and communications are welcome for submission. Reviews should emphasize the reproducibility of previous findings.

Prof. Dr. Chunyu Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Epigenomes is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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Review

20 pages, 2416 KiB  
Review
Epigenetic Regulation of Neural Stem Cells in Developmental and Adult Stages
by Shu Kunoh, Hideyuki Nakashima and Kinichi Nakashima
Epigenomes 2024, 8(2), 22; https://doi.org/10.3390/epigenomes8020022 - 4 Jun 2024
Viewed by 2082
Abstract
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neurons and two types of glial cells (astrocytes and oligodendrocytes), [...] Read more.
The development of the nervous system is regulated by numerous intracellular molecules and cellular signals that interact temporally and spatially with the extracellular microenvironment. The three major cell types in the brain, i.e., neurons and two types of glial cells (astrocytes and oligodendrocytes), are generated from common multipotent neural stem cells (NSCs) throughout life. However, NSCs do not have this multipotentiality from the beginning. During cortical development, NSCs sequentially obtain abilities to differentiate into neurons and glial cells in response to combinations of spatiotemporally modulated cell-intrinsic epigenetic alterations and extrinsic factors. After the completion of brain development, a limited population of NSCs remains in the adult brain and continues to produce neurons (adult neurogenesis), thus contributing to learning and memory. Many biological aspects of brain development and adult neurogenesis are regulated by epigenetic changes via behavioral control of NSCs. Epigenetic dysregulation has also been implicated in the pathogenesis of various brain diseases. Here, we present recent advances in the epigenetic regulation of NSC behavior and its dysregulation in brain disorders. Full article
(This article belongs to the Special Issue Epigenetics of Neurobiology and Brain Diseases)
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11 pages, 807 KiB  
Review
Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
by Toshiyuki Murai and Satoru Matsuda
Epigenomes 2023, 7(3), 20; https://doi.org/10.3390/epigenomes7030020 - 1 Sep 2023
Cited by 1 | Viewed by 2231
Abstract
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases [...] Read more.
Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed. Full article
(This article belongs to the Special Issue Epigenetics of Neurobiology and Brain Diseases)
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