Epigenomic Regulation during Lung Development and Disease

Dear Colleagues,

Due to the constant exposure to the air and environment, the lungs are primary organs for epigenetic changes. Specific epigenomic patterns in different cell types are critical to the normal development of the lungs. The epigenome can be altered under different conditions of the air/environment, resulting specific lung disease. Alterations in DNA/RNA methylation, histone modifications, and noncoding RNAs have all been shown to play critical roles in the development of various lung diseases including asthma, COPD, pulmonary hypertension, lung cancer, and pulmonary fibrosis. These epigenetic changes affect the expression and regulation of key genes that contribute to the pathogenesis of those disorders. Epigenetic modifiers also have the potential to serve as an untapped area for future therapy.

In this Special Issue of Epigenomes, we intend to collect primary research articles and reviews that explore the impact of epigenetic changes in lung development, pathogenesis of various lung related diseases, and highlighting potential epigenetic drugs for therapy in lung related disorders. We also welcome articles that examine the environmental effects of epigenomic changes in lung disease. With respiratory disorders consisting of half of the top six causes of death in the world, a look at how epigenetics affects lung disease will be critical for basic and clincal researchers to find new approaches and advance treatment for related respiratory diseases.

Dr. Yan Y. Sanders
Guest Editor
Dr. Steven K. Huang
Co-Guest Editor

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