Special Issue "Information in Intrinsically Disordered Proteins and Complex Protein Networks"
Deadline for manuscript submissions: closed (31 December 2019).
Interests: intrinsically disordered proteins; protein dynamics; Src-protein kinases; nuclear magnetic resonance; one-dimensional encoding of structural and functional information
Intrinsically disordered proteins (IDP) challenge the classical paradigm that a well-defined folded structure is essential for functioning. Although the loss of a well-defined structure results in the loss of function in many proteins supporting the paradigm, about one third of eukaryotic proteins have long regions that do not adopt a single, well-defined structure in their native state, and another third are nearly completely disordered, yet have important functions. IDP appear functionally linked to complex regulation processes and protein networks.
A new paradigm focusing on the information content encoded by proteins, folded or unfolded, and on their interaction networks is increasingly being recognized.
Classical, quasi-rigid structures represent one possible way of encoding information (like the shape of a key encodes the information to open a lock) but not the only one. If we accept that protein function is a manifestation of its information content, the key question to be answered is how the function-enabling information is encoded in disordered proteins and protein networks.
While the classical lock and key is hardware based, it is likely that the information in disordered proteins is more like a computer program that will interpret a number of cellular input signals to generate a context-dependent response.
In this Special Issue of Entropy, we invite contributions of basic questions related to the following: How is information encoded in the sequence of IDPs? How do conformational ensembles populated by these proteins contribute to the information flow from sequence to function? What is the role of protein dynamics? How is entropy being modulated during the evolution of disordered proteins and their complexes? How are inter- and intra-molecular interaction networks interacting? Why have disordered proteins become essential for eukaryotic life? Is there a programming language for at least some families of intrinsically disordered proteins? Can we reverse engineer IDP software from the observed function?
Conceptual papers, reviews, and research papers presenting computer simulations or experimental approaches are welcome.
Prof. Dr. Miquel Pons
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Entropy is an international peer-reviewed open access monthly journal published by MDPI.
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- Intrinsically disordered proteins
- Protein-Protein interaction networks
- Protein dynamics
- Network dynamics
- Entropy in disordered protein complexes