Special Issue "Information in Intrinsically Disordered Proteins and Complex Protein Networks"
A special issue of Entropy (ISSN 1099-4300).
Deadline for manuscript submissions: 31 December 2019.
Prof. Dr. Miquel Pons
Intrinsically disordered proteins (IDP) challenge the classical paradigm that a well-defined folded structure is essential for functioning. Although the loss of a well-defined structure results in the loss of function in many proteins supporting the paradigm, about one third of eukaryotic proteins have long regions that do not adopt a single, well-defined structure in their native state, and another third are nearly completely disordered, yet have important functions. IDP appear functionally linked to complex regulation processes and protein networks.
A new paradigm focusing on the information content encoded by proteins, folded or unfolded, and on their interaction networks is increasingly being recognized.
Classical, quasi-rigid structures represent one possible way of encoding information (like the shape of a key encodes the information to open a lock) but not the only one. If we accept that protein function is a manifestation of its information content, the key question to be answered is how the function-enabling information is encoded in disordered proteins and protein networks.
While the classical lock and key is hardware based, it is likely that the information in disordered proteins is more like a computer program that will interpret a number of cellular input signals to generate a context-dependent response.
In this Special Issue of Entropy, we invite contributions of basic questions related to the following: How is information encoded in the sequence of IDPs? How do conformational ensembles populated by these proteins contribute to the information flow from sequence to function? What is the role of protein dynamics? How is entropy being modulated during the evolution of disordered proteins and their complexes? How are inter- and intra-molecular interaction networks interacting? Why have disordered proteins become essential for eukaryotic life? Is there a programming language for at least some families of intrinsically disordered proteins? Can we reverse engineer IDP software from the observed function?
Conceptual papers, reviews, and research papers presenting computer simulations or experimental approaches are welcome.
Prof. Dr. Miquel Pons
Manuscript Submission Information
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- Intrinsically disordered proteins
- Protein-Protein interaction networks
- Protein dynamics
- Network dynamics
- Entropy in disordered protein complexes