In Vitro Diagnostics

Dear Colleagues,

There have been tremendous advances in the field of in vitro diagnostics (IVD) during the last two decades, which have led to the development of new IVD technologies and devices. Apart from remarkable advances in biomolecular immobilization, conjugation and surface modification strategies, significant improvements have been made in conventional IVD formats, such as enzyme-linked immunosorbent assay (ELISA) and lateral flow assays. The surface plasmon resonance-based instruments have led to a plethora of real-time label-free assays and have been widely adopted in industries, academia and healthcare. On the other hand, microfluidics-based IVD assays and lab-on-a-chip diagnostic platforms have inculcated tremendous interest among researchers based on their numerous advantages that are apparent to the scientific community. The ongoing research efforts are focused on the integration of microfluidics with lab-on-a-chip, automation and multiplexing capabilities. The use of nanomaterials has further led to naked-eye and signal enhanced assays, which are paving way to interesting bioanalytical applications. The development of paper-based IVD assays will be highly useful for developing nations, due to the significantly reduced analysis cost. Various novel biosensors and assay formats have also been developed. The last few years have seen a dramatic change in the landscape of IVD based on the emergence of smartphones as a point-of-care diagnostic device. Several low-cost smartphone-based devices have been developed and a wide range of diagnostic assays and bioanalytical applications have been demonstrated. These devices hold tremendous potential for mobile Healthcare and personalized medicine. The coming years will witness breakthroughs in IVD that will pave way to next-generation of rapid, low-cost, analytically superior and robust assays and devices.

Dr. Sandeep Kumar Vashist
Guest Editor

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