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The Additional Value of 18F-FDG PET and MRI in Patients with Glioma: A Review of the Literature from 2015 to 2020

Nuclear Medicine Unit, A.R.N.A.S. Ospedali Civico, Di Cristina e Benfratelli, 90127 Palermo, Italy
Committee of AIMN Pediatric Study Group, 20159 Milan, Italy
Nuclear Medicine Unit, Department of Biomedical and Dental Sciences and Morpho-Functional Imaging, University of Messina, 98125 Messina, Italy
AIMN -Italian Association of Nuclear Medicine- Young Members Working Group, 20159 Milan, Italy
Department of Neurosciences, Imaging and Clinical Sciences, “G. d’Annunzio” University, 66100 Chieti, Italy
Nuclear Medicine Department, Ente Ospedaliero Ospedali Galliera, Italy, Mura delle Cappuccine, 14, 16128 Genova, Italy
Committee of AIMN Neuroimaging Study Group, 20159 Milan, Italy
Coordinator of AIMN Paediatric Study Group, 20159 Milan, Italy
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 357;
Received: 31 March 2020 / Revised: 15 May 2020 / Accepted: 27 May 2020 / Published: 29 May 2020
(This article belongs to the Special Issue Molecular Diagnostics of CNS Tumours)
Aim: Beyond brain computed tomography (CT) scan, Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) hold paramount importance in neuro-oncology. The aim of this narrative review is to discuss the literature from 2015 to 2020, showing advantages or complementary information of fluorine-18 fluorodeoxyglucose (18F-FDG) PET imaging to the anatomical and functional data offered by MRI in patients with glioma. Methods: A comprehensive Pubmed/MEDLINE literature search was performed to retrieve original studies, with a minimum of 10 glioma patients, published from 2015 until the end of April 2020, on the use of 18F-FDG PET in conjunction with MRI. Results: Twenty-two articles were selected. Combined use of the two modalities improves the accuracy in predicting prognosis, planning treatments, and evaluating recurrence. Conclusion: According to the recent literature, 18F-FDG PET provides different and complementary information to MRI and may enhance performance in the whole management of gliomas. Therefore, integrated PET/MRI may be particularly useful in gliomas, since it could provide accurate morphological and metabolic information in one-shoot examination and improve the diagnostic value compared to each of procedures. View Full-Text
Keywords: 18F-FDG; PET; MRI; glioma 18F-FDG; PET; MRI; glioma
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Quartuccio, N.; Laudicella, R.; Vento, A.; Pignata, S.; Mattoli, M.V.; Filice, R.; Comis, A.D.; Arnone, A.; Baldari, S.; Cabria, M.; Cistaro, A. The Additional Value of 18F-FDG PET and MRI in Patients with Glioma: A Review of the Literature from 2015 to 2020. Diagnostics 2020, 10, 357.

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