Artificial Intelligence Applications in the Diagnosis and Prevention of Hospital-Acquired Infections

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Machine Learning and Artificial Intelligence in Diagnostics".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 2813

Special Issue Editors


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Guest Editor
1. Department of Medical Diagnostic Imaging, College of Health Science, University of Sharjah, Sharjah 27272, United Arab Emirates
2. Operational Research Centre in Healthcare, Near East University, TRNC Mersin 10, Nicosia 99138, Turkey
Interests: AI in healthcare; decision making in healthcare; medical imaging; nuclear medicine imaging devices
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Guest Editor
Department of Medical Microbiology and Clinical Microbiology, Faculty of Medicine, Near East University, Nicosia 99138, Turkey
Interests: host–pathogen interactions; hospital-acquired infections; antibiotic resistance/epidemiology and antimicrobial drug/vaccine discovery

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Guest Editor
1. Brain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY 10065, USA
2.Operational Research Centre in Healthcare, Near East University, TRNC Mersin 10, Nicosia 99138, Turkey;
Interests: medical imaging; radiology; operational research; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hospital-acquired infections, also known as healthcare-associated infections (HAI), are nosocomially acquired infections that are typically not present or incubating at the time of admission. These infections are usually acquired after hospitalization and manifest 48 hours after admission to the hospital. These infections mainly include catheter-associated urinary tract infections, central line-associated bloodstream infections, surgical site infections, ventilator-associated pneumonia, hospital-acquired pneumonia, and Clostridium difficile infections. HAIs represent a major global public health problem and are associated with increased morbidity and mortality as well as excess healthcare costs. About 1.7 million HAIs with antibiotic-resistant bacteria (superbugs) occur each year. These bacteria include but are not limited to extended-spectrum beta-lactamase-producing Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium, and multi-drug-resistant (MDR) Acinetobacter baumannii.

Recently, artificial intelligence (AI) and machine learning (ML) applications have been exploited to diagnose, control, and prevent HAIs by supporting the development of HAI surveillance algorithms aimed at understanding the HAI risk factors and improving patient risk stratification and the identification of transmission pathways. Prediction of antimicrobial resistance, outbreaks or infection complications in the hospital setting, automated tracking of hand hygiene compliance, automated laboratory diagnosis, and automated antibiotic prescriptions to prevent misuse or overuse of antibiotics are among the data-analytics-driven uses of AI in the field.

We welcome all submissions related to the above-mentioned topics, which are aimed at the detection, diagnosis, control, and prevention of life-threatening HAIs.

Dr. Dilber Uzun Ozsahin
Dr. Buket Baddal
Dr. Ilker Ozsahin
Guest Editors

Manuscript Submission Information

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Keywords

  • hospital-acquired infections
  • multi-drug resistant (MDR) pathogens
  • bacterial infections
  • intensive care unit acquired infections
  • machine learning
  • laboratory diagnosis
  • infection prediction
  • risk factor prediction
  • forecasting
  • AI in infection prevention and control

Published Papers (2 papers)

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11 pages, 1773 KiB  
Article
A Web-Based Dynamic Nomogram to Predict the Risk of Methicillin-Resistant Staphylococcal Infection in Patients with Pneumonia
by Van Duong-Thi-Thanh, Binh Truong-Quang, Phu Tran-Nguyen-Trong, Mai Le-Phuong, Phu Truong-Thien, Dung Lam-Quoc, Thong Dang-Vu, Minh-Loi Nguyen and Vu Le-Thuong
Diagnostics 2024, 14(6), 633; https://doi.org/10.3390/diagnostics14060633 - 16 Mar 2024
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Abstract
The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to [...] Read more.
The aim of this study was to create a dynamic web-based tool to predict the risks of methicillin-resistant Staphylococcus spp. (MRS) infection in patients with pneumonia. We conducted an observational study of patients with pneumonia at Cho Ray Hospital from March 2021 to March 2023. The Bayesian model averaging method and stepwise selection were applied to identify different sets of independent predictors. The final model was internally validated using the bootstrap method. We used receiver operator characteristic (ROC) curve, calibration, and decision curve analyses to assess the nomogram model’s predictive performance. Based on the American Thoracic Society, British Thoracic Society recommendations, and our data, we developed a model with significant risk factors, including tracheostomies or endotracheal tubes, skin infections, pleural effusions, and pneumatoceles, and used 0.3 as the optimal cut-off point. ROC curve analysis indicated an area under the curve of 0.7 (0.63–0.77) in the dataset and 0.71 (0.64–0.78) in 1000 bootstrap samples, with sensitivities of 92.39% and 91.11%, respectively. Calibration analysis demonstrated good agreement between the observed and predicted probability curves. When the threshold is above 0.3, we recommend empiric antibiotic therapy for MRS. The web-based dynamic interface also makes our model easier to use. Full article
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42 pages, 1436 KiB  
Systematic Review
Harnessing of Artificial Intelligence for the Diagnosis and Prevention of Hospital-Acquired Infections: A Systematic Review
by Buket Baddal, Ferdiye Taner and Dilber Uzun Ozsahin
Diagnostics 2024, 14(5), 484; https://doi.org/10.3390/diagnostics14050484 - 23 Feb 2024
Cited by 1 | Viewed by 1317
Abstract
Healthcare-associated infections (HAIs) are the most common adverse events in healthcare and constitute a major global public health concern. Surveillance represents the foundation for the effective prevention and control of HAIs, yet conventional surveillance is costly and labor intensive. Artificial intelligence (AI) and [...] Read more.
Healthcare-associated infections (HAIs) are the most common adverse events in healthcare and constitute a major global public health concern. Surveillance represents the foundation for the effective prevention and control of HAIs, yet conventional surveillance is costly and labor intensive. Artificial intelligence (AI) and machine learning (ML) have the potential to support the development of HAI surveillance algorithms for the understanding of HAI risk factors, the improvement of patient risk stratification as well as the prediction and timely detection and prevention of infections. AI-supported systems have so far been explored for clinical laboratory testing and imaging diagnosis, antimicrobial resistance profiling, antibiotic discovery and prediction-based clinical decision support tools in terms of HAIs. This review aims to provide a comprehensive summary of the current literature on AI applications in the field of HAIs and discuss the future potentials of this emerging technology in infection practice. Following the PRISMA guidelines, this study examined the articles in databases including PubMed and Scopus until November 2023, which were screened based on the inclusion and exclusion criteria, resulting in 162 included articles. By elucidating the advancements in the field, we aim to highlight the potential applications of AI in the field, report related issues and shortcomings and discuss the future directions. Full article
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