Pathogenesis and Treatment of Acne

A special issue of Dermato (ISSN 2673-6179).

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 9232

Special Issue Editors


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Guest Editor
Laboratory for Cellular and Molecular Physiology, Department of Physiology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: cannabinoid signaling; phytocannabinoids; mitochondrial biology; acne; (patho)biology of hair follicles; inflammatory skin diseases

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Guest Editor
Department of Dermatology, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary
Interests: acne; sebocytes; lipids, isotretinoin; skin inflammation
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Special Issue Information

Dear Colleagues,

Acne is one of the most common skin diseases. Although it is not a directly life-threatening condition, it can severely impair the quality of life of patients, leading to psycho-emotional distress characterized by, e.g., anxiety, depression, or suicidal ideation.

Importantly, although our knowledge on the pathogenesis of the disease has expanded substantially in recent years, no new chemical entities (i.e., not combinations or derivatives of previously introduced drugs) have been approved by the FDA in the last two decades for the treatment of acne. Thus, considering the potentially severe side effect profile of the top anti-acne agents (e.g., isotretinoin), there is an unmet demand from the medical community, pharmaceutical industry, and society to find new, efficient, yet safe solutions to treat acne.

To respond to this challenge, this Special Issue calls for original research, reviews, case studies, and perspectives that may expand the current knowledge on the pathogenesis of acne and thereby have the potential to lead to the development of innovative, new approaches in the treatment of the disease.

Dr. Attila Oláh
Dr. Dániel Törőcsik
Guest Editors

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Keywords

  • Acne
  • C. acnes
  • Comedogenesis
  • Inflammation
  • Immune cells
  • Microbiota–host communication
  • Sebaceous gland
  • Seborrhea
  • Lipids
  • Signaling
  • Therapeutic target
  • Scarring

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Published Papers (1 paper)

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Review

12 pages, 1245 KiB  
Review
Association of Acne Tarda with Endocrinological Disorders
by Evgenia Makrantonaki and Christos C. Zouboulis
Dermato 2022, 2(4), 109-120; https://doi.org/10.3390/dermato2040010 - 28 Sep 2022
Cited by 2 | Viewed by 8359
Abstract
Acne tarda is defined as acne that develops (late-onset acne) or continues (persistent acne) after 25 years of age. The disease is more common in women. The etiology of acne tarda is still controversial, and a variety of factors such as endocrinological disorders [...] Read more.
Acne tarda is defined as acne that develops (late-onset acne) or continues (persistent acne) after 25 years of age. The disease is more common in women. The etiology of acne tarda is still controversial, and a variety of factors such as endocrinological disorders including hyperandrogenism and hyperandrogenemia, stress, modern western diet, ultraviolet irradiation, drugs and cosmetics have been implicated. In particular, women with acne tarda and other symptoms of hyperandrogenism such as hirsutism and androgenetic alopecia have a high probability of endocrine abnormalities such as polycystic ovarian syndrome, primary ovarian insufficiency, Cushing’s syndrome and late-onset adrenogenital syndrome. Virilization is a relatively uncommon feature of hyperandrogenemia and its presence often suggests an androgen-producing tumor. Treatment is similar to that of acne in adolescence; however, long-term treatment over years or decades may be required. A thorough history, a focused clinical examination and an interdisciplinary approach together with gynecologists and endocrinologists are extremely helpful in diagnostic evaluation and therapy of patients with acne tarda. Full article
(This article belongs to the Special Issue Pathogenesis and Treatment of Acne)
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