Special Issue "Advances in Squamous Cell Carcinoma of the Head and Neck"
Deadline for manuscript submissions: 1 November 2022 | Viewed by 2390
Interests: bile reflux; carcinogens; NF-kappa B; STAT3 transcription factor; DNA mismatch repair; laryngopharyngeal reflux; squamous cell carcinoma of head and neck
Head and neck cancer account for about 4% of all cancers in The United States. However, it is estimated that approximately 66,630 new cases (48,740 men and 17,890 women) and 14,620 deaths (10,640 men and 3980 women) from head and neck cancer will occur in the United States in 2021. From a clinical perspective, laryngopharyngeal tumors, which account for almost 50% of all head and neck cancers (HNSCC), are very aggressive, causing high levels of functional morbidity and mortality, with an overall 5-year survival rate of approximately 60% and are therefore considered among the most devastating cancers. Known risk factors, such as smoking, alcohol consumption, and HPV16 infection have been associated with HNSCC. Additional risk factors, such as laryngopharyngeal reﬂux (LPR), have also been linked to the disease. The pathogenesis of HNSCC and its therapeutic targeting strategies require further investigation. Identifying and characterizing the mechanism of the neoplastic process that is activated under the influence of variable risk factors would ultimately allow a more comprehensive risk stratiﬁcation and prevention of HNSCC, such as laryngopharyngeal cancer or its recurrences, including the development of therapeutic strategies.
In this Special Issue of Current Oncology, we invite research reports focused on new advances on head and neck squamous cell carcinoma (HNSCC) risk factors, prevention, and novel therapy; specifically, these topics may include:
- HNSCC epidemiology;
- HNSCC etiopathogenesis and prevention;
- HNSCC novel targets and biomarkers;
- Advances of HNSCC therapeutic strategies.
Dr. Dimitra P. Vageli
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- head and neck carcinogenesis
- laryngopharyngeal cancer
- hypopharyngeal cancer
- cause, prevention, and therapy