Therapeutic Studies from Pre-Clinical to Clinical (Phase I–IV) for Gastrointestinal Cancers

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 402

Special Issue Editor


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Guest Editor
Princess Margaret Cancer Centre, Toronto, ON M5G 2C4, Canada
Interests: medical oncology; gastrointestinal cancers; clinical trials; personalized treatment

Special Issue Information

Dear Colleagues,

Clinical trials remain the standard of care across the field of oncology to introduce novel treatment strategies and agents. These often evolve from promising preclinical data to drug development across Phase I–III trials, with varying levels of success. New treatments for all gastrointestinal malignancies are needed to prolong survival and maintain quality of life.

In this Special Issue of Current Oncology, we invite authors to submit work focusing on therapeutic studies across the spectrum, from preclinical data to later-stage clinical trials, on gastrointestinal cancers. Original articles, as well as review articles detailing advances in novel therapeutics, are welcome. We look forward to receiving your contributions.

Dr. Erica S. Tsang
Guest Editor

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • gastrointestinal cancers
  • novel treatments
  • targeted therapies
  • immunotherapies
  • vaccine therapies

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Published Papers (1 paper)

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Research

12 pages, 663 KiB  
Article
Renal Function Deterioration in Postoperative (Adjuvant) Chemotherapy for Colon Cancer—Real-Life Data
by Aleksandra Gładyś, Sylwia Kozak, Aleksander Jerzy Owczarek, Ewa Cedrych, Zofia Irena Niemir, Stanisław Łącki-Zynzeling, Anna Chudek, Izolda Mrochen-Domin, Iwona Gisterek-Grocholska and Jerzy Chudek
Curr. Oncol. 2025, 32(6), 351; https://doi.org/10.3390/curroncol32060351 - 13 Jun 2025
Viewed by 194
Abstract
The knowledge concerning mild-to-moderate renal toxicity of adjuvant chemotherapy (CTH) in colon cancer patients is scarce. We retrospectively evaluated changes in the estimated glomerular filtration rate (eGFR) after three months of adjuvant treatment and the overall renal risk of the 6-month regimen in [...] Read more.
The knowledge concerning mild-to-moderate renal toxicity of adjuvant chemotherapy (CTH) in colon cancer patients is scarce. We retrospectively evaluated changes in the estimated glomerular filtration rate (eGFR) after three months of adjuvant treatment and the overall renal risk of the 6-month regimen in 145 patients who completed three months of therapy at three oncological centers. A decrease in eGFR of at least 1.5 mL/min/1.73 m2 after three months and 3.0 mL/min/1.73 m2 after six months was considered relevant in terms of kidney-related cardiovascular risk. Out of 114 patients who completed a 6-month regimen, kidney function deterioration occurred in 62 (54.4%) after 3 months and in 54 (47.4%) after 6 months. Age ≥ 70 years (RR = 2.66; 95% CI: 1.15–6.16) and diabetes (RR = 2.52; 95% CI: 0.98–6.45) were risk factors for kidney outcomes during the first three months of CTH. However, renal function decline during the first three months did not increase the risk of further deterioration on CTH continuation. In conclusion, older age and diabetes are factors increasing the risk of renal function deterioration during adjuvant CTH in colon cancer patients without preexisting chronic kidney disease. However, the decline during the first three months does not allow for predicting further changes under continued adjuvant therapy. Full article
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