Advances in Endocrine Therapy for Breast Cancer

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Breast Cancer".

Deadline for manuscript submissions: 31 August 2026 | Viewed by 1260

Special Issue Editors


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Guest Editor
Ottawa Hospital Research Institute, Ottawa, ON, Canada
Interests: oncology; breast cancer; skin cancer; melanoma; advocacy; access

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Guest Editor
Department of Medicine, The Ottawa Hospital, Ottawa, ON, Canada
Interests: breast cancer; genomics; proteomics, precision oncology; clinical trials

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Guest Editor
Department of Medicine, The University of British Columbia, and BC Cancer, Vancouver, BC, Canada
Interests: breast cancer; clinical trials; new cancer therapies; drug development; biomarkers

Special Issue Information

Dear Colleagues,

We invite you to contribute original research, reviews, and expert perspectives to an upcoming Special Issue of our Current Oncology titled “Advances in Endocrine Therapy for Breast Cancer.” This Special Issue will highlight emerging discoveries and innovations shaping the future of hormone-responsive breast cancer care.

Hormone receptor-positive breast cancer, the most common subtype, has a long history of successful treatment using endocrine therapies in both the early and advanced stages of disease. Rapid progress, including novel SERDs, targeted combinations, biomarkers of resistance, and evolving strategies for treatment sequencing, has created an exciting and fast-moving field.

For this Special Issue, we welcome manuscripts focusing on recent advancements in novel endocrine agents, mechanisms, and detection of endocrine resistance, translational and biomarker research, toxicity mitigation and survivorship, disparities in care, and advancements in both metastatic and early disease settings. We also welcome systematic reviews, cost-effectiveness studies, and research into patient-reported outcomes.

We hope you will consider submitting your research and contributing to this Special Issue advancing endocrine therapy research and patient care.

Dr. Sandeep Sehdev
Dr. Arif Ali Awan
Dr. Karen A. Gelmon
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endocrine therapy
  • breast cancer
  • endocrine resistance
  • CDK 4/6 inhibitor
  • biomarkers
  • selective endocrine receptor degraders (SERDs)

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Published Papers (1 paper)

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Review

20 pages, 1818 KB  
Review
Preclinical Rationale, Clinical Efficacy, and Safety of the Selective AKT Kinase Inhibitor Capivasertib in Metastatic Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Breast Carcinoma: A Practical Narrative Review
by Maria Rosaria Valerio, Daniela Sambataro, Federica Martorana, Martina Greco, Chiara Mesi, Vittorio Gebbia, Paolo Vigneri and Giuseppa Scandurra
Curr. Oncol. 2026, 33(4), 198; https://doi.org/10.3390/curroncol33040198 - 31 Mar 2026
Viewed by 870
Abstract
Most patients with advanced/metastatic hormone receptor-positive, HER2-negative breast cancer receive first-line therapy with cycline-dependent kinase 4/6 inhibitors plus endocrine therapy. Almost universally, these patients eventually progress due to the emergence of resistant cancer clones. Targeting the PIK3CA/AKT1/PTEN pathway is a way of overcoming [...] Read more.
Most patients with advanced/metastatic hormone receptor-positive, HER2-negative breast cancer receive first-line therapy with cycline-dependent kinase 4/6 inhibitors plus endocrine therapy. Almost universally, these patients eventually progress due to the emergence of resistant cancer clones. Targeting the PIK3CA/AKT1/PTEN pathway is a way of overcoming resistance. Recently, the oral, selective AKT kinase inhibitor capivasertib has been approved for the treatment of estrogen receptor-positive/human HER2-growth factor receptor-2 advanced BC with alterations in PIK3CA/AKT1/PTEN, in combination with fulvestrant after progression on endocrine therapy. We performed a narrative review to recapitulate the available evidence about capivasertib in the management of advanced hormone receptor-positive, HER2-negative breast cancer, focusing on studies that address preclinical rationale, pharmacology, and clinically relevant problems. Full article
(This article belongs to the Special Issue Advances in Endocrine Therapy for Breast Cancer)
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