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Current Oncology
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Bridging Borders: A Global Perspective on Colorectal Cancer Research and...
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Bridging Borders: A Global Perspective on Colorectal Cancer Research and Prevention

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: closed (28 February 2026) | Viewed by 6964

Special Issue Editor

Prof. Dr. Laith Alrubaiy

E-Mail Website
Guest Editor
Faculty of Medicine Health and Life Science, Swansea University, Swansea SA2 8QA, UK
Interests: colorectal cancer; colon cancer; artificial intelligence; colonoscopy; cancer screening
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Colorectal cancer (CRC) remains a significant global health challenge, with disparities in incidence, screening, and outcomes across regions. This Special Issue, “Bridging Borders: A Global Perspective on Colorectal Cancer Research and Prevention”, aims to foster international collaboration and knowledge exchange in the fight against CRC. By highlighting innovative research, preventive strategies, and emerging technologies, we seek to advance global efforts in reducing the burden of this disease.

We invite submissions that explore diverse aspects of colorectal cancer, including, but not limited to, the following:

  • Advances in screening strategies and programs;
  • Application of artificial intelligence in early detection and diagnosis;
  • Insights into regional differences in CRC incidence and outcomes;
  • Culturally tailored interventions for prevention and management;
  • Novel therapeutics and translational research.

This Special Issue aims to bridge geographical and scientific divides, bringing together a wealth of expertise to inspire meaningful progress. We welcome researchers, clinicians, and public health professionals from all disciplines to contribute their findings and perspectives to this global dialogue.

Let us work together to illuminate the path forward in colorectal cancer research and prevention, transcending borders and fostering impactful solutions for a healthier future.

Prof. Dr. Laith Alrubaiy
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • colorectal cancer (CRC)
  • global health
  • mass screening
  • early detection of cancer
  • artificial intelligence (AI)
  • epidemiology
  • health disparities
  • diagnostic technologies
  • public health
  • therapeutics

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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17 pages, 1627 KB  
Article
Co-Occurrence of Nuclear-Catenin and H3K27me3 Expression in Advanced Colorectal Cancer: A Retrospective Observational Study
by Ramona Abrudan, Luca Abrudan, Andreea Cămărășan, Ovidiu Camarasan, Corina Florica Ioniță, Luca Vilceanu and Ovidiu Laurean Pop
Curr. Oncol. 2026, 33(4), 210; https://doi.org/10.3390/curroncol33040210 - 8 Apr 2026
Viewed by 300
Abstract
Colorectal cancer is a heterogeneous malignancy characterized by alterations in oncogenic signaling pathways and epigenetic mechanisms involved in gene regulation. Aberrant activation of the Wnt/β-catenin pathway represents a central molecular event in colorectal tumorigenesis, while histone-associated epigenetic modifications may contribute to tumor progression [...] Read more.
Colorectal cancer is a heterogeneous malignancy characterized by alterations in oncogenic signaling pathways and epigenetic mechanisms involved in gene regulation. Aberrant activation of the Wnt/β-catenin pathway represents a central molecular event in colorectal tumorigenesis, while histone-associated epigenetic modifications may contribute to tumor progression and variability. This study aimed to investigate the relationship between Wnt pathway activation and histone H3 lysine 27 trimethylation in colorectal cancer and to examine their associations with clinicopathological and molecular characteristics. A retrospective observational study was performed on 83 colorectal adenocarcinoma cases using immunohistochemical evaluation of nuclear β-catenin and H3K27me3 expression in formalin-fixed, paraffin-embedded tumor samples, together with molecular analysis of KRAS, NRAS, and BRAF mutations and microsatellite instability status. Nuclear β-catenin expression was observed in 39.8% of cases, while H3K27me3 exhibited negative, mosaic, or diffuse nuclear staining patterns. Nuclear β-catenin expression was significantly associated with patient sex and age, whereas H3K27me3 expression patterns were significantly associated with tumor location, histological grade, disease stage, and metastatic status. These results indicate that Wnt pathway activation and H3K27me3-associated epigenetic alterations frequently coexist in colorectal cancer and support the value of integrated molecular and epigenetic assessment. Full article
(This article belongs to the Special Issue Bridging Borders: A Global Perspective on Colorectal Cancer Research and Prevention)
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Review

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25 pages, 712 KB  
Review
Protective Effects of Plant-Based Diets Against Colorectal Carcinogenesis via Modulation of Key Cellular and Molecular Mechanisms: A Comprehensive Review of Evidence
by Marina Kamel, Clarence Wong, Eduardo Grunvald, Andrea Galli, Sahar Iqbal, Arshdeep Rattol, Tanya Jackson, Sebastian Straube and Ellina Lytvyak
Curr. Oncol. 2026, 33(4), 222; https://doi.org/10.3390/curroncol33040222 - 17 Apr 2026
Viewed by 659
Abstract
Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide and is the second largest contributor to both incidence and mortality, underscoring the urgent need for effective prevention strategies. This comprehensive review provides the most up-to-date evidence on the protective role of [...] Read more.
Colorectal cancer (CRC) remains one of the most prevalent malignancies worldwide and is the second largest contributor to both incidence and mortality, underscoring the urgent need for effective prevention strategies. This comprehensive review provides the most up-to-date evidence on the protective role of plant-based dietary patterns against CRC carcinogenesis, with particular emphasis on underlying cellular and molecular level mechanisms. Accumulating research demonstrates that plant-based foods, rich in dietary fibre, polyphenols, and multiple other bioactive compounds, promote gut microbial eubiosis, support immune regulation, and modulate adipose tissue homeostasis. These effects are accompanied by intestinal barrier integrity, enhanced production of short-chain fatty acids, and the induction of apoptosis in malignant cells. Moreover, plant-derived nutrients reduce the abundance of pro-inflammatory microbial taxa, decrease oxidative, nitrosative and carbonyl stress, and downregulate pro-inflammatory cytokines and signalling pathways, implicated in tumourigenesis. As a result, plant-based dietary patterns have high potential to reduce CRC risk through modulating the intricate interplay between epigenetics, inflammation, immune dysregulation, metabolic and hormonal disruptions, and gut microbiota, suggesting a highly promising, cost-effective and equitable strategy for CRC prevention. Full article
(This article belongs to the Special Issue Bridging Borders: A Global Perspective on Colorectal Cancer Research and Prevention)
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21 pages, 1422 KB  
Review
Cannabidiol (CBD) and Colorectal Tumorigenesis: Potential Dual Modulatory Roles via the Serotonergic Pathway
by Zhenhua Liu
Curr. Oncol. 2025, 32(7), 375; https://doi.org/10.3390/curroncol32070375 - 26 Jun 2025
Cited by 2 | Viewed by 5124
Abstract
The 2018 Farm Bill legalized hemp-derived cannabidiol (CBD) products containing less than 0.3% tetrahydrocannabinol (THC) in the United States. This legislative shift catalyzed both public and scientific interest in CBD’s potential health benefits. However, the rapid expansion of the CBD market has considerably [...] Read more.
The 2018 Farm Bill legalized hemp-derived cannabidiol (CBD) products containing less than 0.3% tetrahydrocannabinol (THC) in the United States. This legislative shift catalyzed both public and scientific interest in CBD’s potential health benefits. However, the rapid expansion of the CBD market has considerably outpaced rigorous scientific research, leaving many health claims largely unsubstantiated. While preclinical studies suggest that CBD may exert antitumorigenic effects in colorectal cancer (CRC) by modulating cell proliferation, apoptosis, and inflammation, clinical evidence supporting these effects remains limited. This review critically examines the current evidence on the role of CBD in colorectal tumorigenesis, with particular attention to its molecular mechanisms and interactions with the serotonergic system—a signaling pathway implicated in the development of CRC and possessing potential dual anti- and pro-tumorigenic properties. By influencing the serotonergic system, CBD may confer both protective and potentially deleterious effects during CRC development. This review underscores the need for further research to elucidate the complex mechanisms of CBD in colorectal tumorigenesis and to evaluate its therapeutic potential in clinical settings. Understanding these interactions could pave the way for novel prevention and treatment strategies, optimizing the anticancer efficacy of CBD while mitigating unintended risks. Full article
(This article belongs to the Special Issue Bridging Borders: A Global Perspective on Colorectal Cancer Research and Prevention)
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