Research on Neoadjuvant Therapy for Gastric Cancer

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Gastrointestinal Oncology".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 1142

Special Issue Editor


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Guest Editor
Radiotherapy Department, Maria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, 44-102 Gliwice, Poland
Interests: neoadjuvant therapy; radiotherapy; oncology

Special Issue Information

Dear Colleagues,

Gastric cancer continues to pose a major health challenge worldwide, with high incidence and mortality rates. The treatment landscape has evolved significantly with the introduction of neoadjuvant therapy, which involves administering therapeutic interventions before surgery to improve outcomes. This Special Issue, "Research on Neoadjuvant Therapy for Gastric Cancer", provides a comprehensive overview of the current state and advancements in this critical area. Combination of surgery and chemotherapy, radiotherapy, and immunotherapy increases treatment effectiveness through sterilization of cancer microfoci not covered by surgical treatment by lowering the risk of locoregional relapse and/or distant metastases, and as a consequence, improvement of long-term results. Furthermore, the primary tumor regression can increase the overall rate of resectability and complete surgery. This issue features cutting-edge research on novel drug regimens, biomarkers for treatment response, and strategies for personalized therapy. We hope this compilation serves as a valuable resource for researchers, clinicians, and policymakers dedicated to advancing gastric cancer treatment and improving patient outcomes.

Prof. Dr. Jerzy Wydmanski
Guest Editor

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Keywords

  • gastric cancer
  • neoadjuvant therapy
  • preoperative treatment
  • radiotherapy
  • chemotherapy
  • targeted therapy
  • immunotherapy
  • tumor resectability
  • treatment response biomarkers
  • personalized therapy

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Published Papers (1 paper)

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Research

15 pages, 972 KB  
Article
Impact of Treatment Modalities on Locally Advanced Gastric Cancer—Real-World Data
by Esma Uguztemur and Banu Oztürk
Curr. Oncol. 2025, 32(8), 463; https://doi.org/10.3390/curroncol32080463 - 16 Aug 2025
Viewed by 725
Abstract
The optimal sequencing of chemotherapy in locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare survival outcomes between adjuvant (ACT) and neoadjuvant (NACT) chemotherapy and to identify clinicopathological factors associated with progression-free survival (PFS) and overall survival (OS) in a [...] Read more.
The optimal sequencing of chemotherapy in locally advanced gastric cancer (LAGC) remains controversial. This study aimed to compare survival outcomes between adjuvant (ACT) and neoadjuvant (NACT) chemotherapy and to identify clinicopathological factors associated with progression-free survival (PFS) and overall survival (OS) in a real-world setting. Methods: We retrospectively analyzed 103 patients with non-metastatic gastric cancer treated between 2014 and 2024. Patients were categorized into ACT (n = 56) and NACT (n = 47) groups. Kaplan–Meier and Cox regression analyses were used to assess survival outcomes and prognostic factors. Results: The NACT group was younger and had more proximal tumors. Median OS was 48.7 months in the ACT group versus 17.7 months in the NACT group (p = 0.048). Median PFS was not reached in the ACT group and was 15.6 months in the NACT group (p = 0.008). Negative surgical margin status was independently associated with improved survival, whereas age was an independent negative prognostic factor for OS. No significant associations were found between OS or PFS and histologic subtype, lymphovascular invasion, perineural invasion, gender, D2 dissection, or type of surgery. Notably, 21% of NACT patients did not proceed to surgery due to progression, treatment intolerance, or refusal. Conclusion: Although ACT was associated with longer PFS and OS in this cohort, these differences are most likely explained by baseline imbalances, patient selection factors, and survivorship bias rather than the timing of chemotherapy itself. These findings highlight the importance of careful patient selection for NACT and underscore the need for prospective, randomized studies to define optimal sequencing strategies in LAGC. Our study contributes descriptive, real-world data rather than definitive evidence of treatment superiority. Full article
(This article belongs to the Special Issue Research on Neoadjuvant Therapy for Gastric Cancer)
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