Pancreatic Cancer: From Novel Biomarkers to More Efficient Therapies
A special issue of Current Oncology (ISSN 1718-7729).
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 5160
Special Issue Editor
Interests: pancreatic cancer; perineural invasion; pain; NGF; neutrophins
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult tumors to treat. Radical surgery is the only potentially curative treatment, though, even in the group of radically resected patients, the five-year survival rate is below 25%. There are several reasons for the dismal prognosis of PDAC, in particular the late onset of symptoms, the biological aggressiveness characterized by early metastasis and the impressive resistance to many anticancer agents.
Unfortunately, progress in the management of both resectable and borderline resectable PDAC, but especially of locally advanced/metastatic disease, has been very modest in recent decades. In fact, chemotherapy regimens (gemcitabine and abraxane or FOLFIRINOX) are the gold standard in the treatment of locally advanced or metastatic PDAC, despite providing only slight improvements in overall survival, reaching at best a few months. No target therapies and no immunotherapy approaches are nowadays clearly effective against PDAC, and no predictive biomarkers of treatment effectiveness are used routinely in clinical practice. Only the implementation of genetic testing can change a very narrow treatment landscape for small subsets of patients with actionable aberrations. In particular, in BRCA1/2 mutated setting, olaparib (PARP inhibitor) might be proposed as a maintenance strategy. Therefore, novel therapies and biomarkers are needed in order to predict effectiveness/resistance to treatments.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- predictive and prognostic biomarkers in PDAC
- translational research with the potential to increase the efficacy of actual treatments
- neoadjuvant therapy in resectable/borderline resectable PDAC
- adjuvant therapy in PDAC
- metastatic treatment possibilities in PDAC
We look forward to receiving your contributions.
Dr. Ingrid Garajová
Guest Editor
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Keywords
- pancreatic cancer
- biomarker
- neoadjuvant therapy
- target therapy
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