Brain Health

Special Issue Editors


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Guest Editor
Department of Neurology, Inselspital University Hospital of Bern, Bern, Switzerland
Interests: general neurology; sleep-wake medicine; coma/disorders of consciousness; stroke medicine; Parkinson's movement disorders
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Co-Guest Editor
Department of Neurology, University Hospital of Geneva and University of Geneva, Geneva, Switzerland
Interests: cerebral small vessel diseases; cerebral amyloid angiopathy; vascular cognitive impairment and dementia; Alzheimer’s disease

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Co-Guest Editor
Department of Neurology, University of Zurich, Zurich, Switzerland
Interests: MRI data of deep neural networks in acute stroke

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Co-Guest Editor
Department of Psychiatry, Université de Genève, Geneva, Switzerland
Interests: apathy; cognitive deficits; schizophrenia; transcranial magnetic stimulation; translational psychiatry

Special Issue Information

Dear Colleagues,

We are pleased to announce the launch of a Special Issue entitled “Brain Health” in the MDPI journal Clinical and Translational Neuroscience.

Our brain plays a crucial role in all aspects of our lives; it is essential for cognitive, motor, and sensory functions, as well as our experiences, emotions, and behavior. In addition, it influences vascular, endocrine, and immunological processes in our body. Ultimately, the brain and its health are essential for our individual (physical, mental, social, and spiritual) wellbeing, for unlocking our potential (in terms of knowledge, skills, and creativity) as individuals, and for the sustainable development of a fair, well-functioning, and productive society.

According to the World Health Organization (WHO) and recent peer-reviewed publications, more than one in three people is affected by a neurological disorder (ND), and at least one in three is affected by a mental (psychiatric) disorder (MD). Brain disorders surpass cardiovascular disorders and cancer combined in terms of disability, mortality, and costs.

The “Brain Health” Special Issue is dedicated to not only advancing basic and translational knowledge, but also to fostering international collaborations and initiatives to promote brain health and science-based prevention of brain disorders throughout the life course for all people worldwide.

We eagerly await your submissions to contribute to this crucial conversation about brain health.

Warm regards,

Prof. Dr. Claudio Bassetti
Dr. Lukas Sveikata
Prof. Dr. Susanne Wegener
Prof. Dr. Indrit Bègue
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • brain health
  • cognitive functions
  • physical, mental, social, and spiritual wellbeing motor and sensory functions
  • neurological disorder
  • mental (psychiatric) disorder

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Published Papers (2 papers)

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Review

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15 pages, 1374 KiB  
Review
Sleep Health
by Albrecht P. A. Vorster, Eus J. W. van Someren, Allan I. Pack, Reto Huber, Markus H. Schmidt and Claudio L. A. Bassetti
Clin. Transl. Neurosci. 2024, 8(1), 8; https://doi.org/10.3390/ctn8010008 - 24 Jan 2024
Cited by 2 | Viewed by 4283
Abstract
Together with (physical and mental) exercise, diet, and social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part of this review, we present the current knowledge on how sleep promotes body, [...] Read more.
Together with (physical and mental) exercise, diet, and social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part of this review, we present the current knowledge on how sleep promotes body, brain, mental, occupational, and social health as well as creativity, productivity, and well-being. In the second part, we discuss how good sleep and screening for sleep–wake disorders may improve health and reduce the burden of brain, mental, cardiovascular, metabolic disorders and cancer. We also review the literature on measurements of sleep health and present the Bernese Sleep Health Questionnaire, a new and simple tool to assess sleep health and screen for sleep–wake circadian disorders in clinical practice. Full article
(This article belongs to the Special Issue Brain Health)
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8 pages, 1424 KiB  
Case Report
Frequently Suspected, Rarely Confirmed: The Complex Diagnostic Journey of Adult-Onset MELAS—Clinical Evaluation and Cost Implications
by Sebastian Finkener, Arkady Ovchinnikov, Ronald Bauer, Michael Diepers and Markus Gschwind
Clin. Transl. Neurosci. 2024, 8(4), 30; https://doi.org/10.3390/ctn8040030 - 30 Nov 2024
Viewed by 538
Abstract
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a rare mitochondrial disorder primarily presenting in pediatric patients, with onset after 40 years being exceptionally rare (1–6%). Here, we report a complex diagnostic journey of a 47-year-old male presenting with new-onset seizures, hemiparesis, [...] Read more.
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a rare mitochondrial disorder primarily presenting in pediatric patients, with onset after 40 years being exceptionally rare (1–6%). Here, we report a complex diagnostic journey of a 47-year-old male presenting with new-onset seizures, hemiparesis, and neurocognitive deficits. Initial work-up, including MRI, CSF analysis, and extensive antibody screening, yielded inconclusive results, prompting differential considerations such as autoimmune encephalitis and neoplastic conditions. Finally muscle biopsy findings, coupled with genetic confirmation of the m.3243A>G mutation in the MT-TL1 gene, ultimately established the diagnosis of MELAS. This case depicts the atypical presentation of adult-onset MELAS without initial lactic acidemia, diabetes, or hearing impairment. The prolonged diagnostic process underscores the challenges of identifying rare diseases under today’s financial and administrative constraints. Still ee emphasize the importance of comprehensive diagnostics in rare cases to advance generall understanding and improve future patient outcomes, also amidst resource limitations. Full article
(This article belongs to the Special Issue Brain Health)
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