Skin Care and Innovation from the Perspective of Molecular Dermatology

A special issue of Cosmetics (ISSN 2079-9284). This special issue belongs to the section "Cosmetic Dermatology".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2208

Special Issue Editors


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Guest Editor
Hexis Lab, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK
Interests: molecular dermatology; premature ageing; systems biology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Hexis Lab, Newcastle Helix, Newcastle upon Tyne NE4 5BX, UK
Interests: personalised skincare; skin phenotypes; artificial intelligence; skin physiology
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Division of Dermatology, Venereology and Clinical Immunology, Faculty of Medicine, Wroclaw University of Science and Technology, 51-377 Wroclaw, Poland
2. Department of Dermato-Venereology, 4th Military Hospital, 50-981 Worclaw, Poland
Interests: medical mycology; superfical mycoses; dermatophytoses; epidemiology; diagnosis and treatment of tineas; psychosocial aspects of fungal infections
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As a Guest Editor, I am pleased to introduce this Special Issue in the journal Cosmetics, entitled “Skin Care and Innovation from the Perspective of Molecular Dermatology”. Human skin comprises diverse cellular components, each engaged in complex biological processes at the systemic level. Understanding these multifaceted characteristics is essential, as they influence the effectiveness of personalised skincare strategies.

This Special Issue aims to illuminate the importance of integrative skin biology and emphasize individual skin-type concerns. This Special Issue is dedicated to exploring specific areas that warrant a focused approach to personalisation in skin care, namely pigmentation, epidermal barrier, and superficial dermis. This Special Issue will also examine the impact of environmental factors and the ageing process on these characteristics in relation to overall skin health and appearance.

Products designed for individual skin types must deliver active ingredients that restore the skin function and maintain a healthy appearance. Innovation relies on research, as the integration of specialised products based on natural and repositioned ingredients targeting specific molecular components could be tailored for each skin type individually.

We invite contributions that help to address the long-overlooked demand for progress in personalised skin care approaches. Original research articles, reviews, and perspectives focused on the biology of skin-type-specific cells, the integumentary system biology, genomic data, and up-to-date biomarkers linked to skin ethnicity are encouraged. We also welcome developments that examine novel ingredients and comprehensive efficacy studies that enrich our understanding of personalised skin care.

As we look ahead, the emphasis on innovation is essential for a deeper understanding of the molecular mechanisms and complexities of skin care.

You may choose our Joint Special Issue in Life.

Dr. Ewa Markiewicz
Dr. Olusola Idowu
Prof. Dr. Jacek C Szepietowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cosmetics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular dermatology
  • personalised skincare
  • ageing
  • natural ingredients

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Published Papers (1 paper)

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Research

16 pages, 2428 KB  
Article
Upcycled Postbiotic Cell-Free Supernatants from Limosilactobacillus fermentum MG901 and MG4237 Alleviated Oxidative Stress-Induced Dysfunction in Human Follicle Dermal Papilla Cells
by Chae Young Jeon, Ji Yeon Lee, Jungwon Min, Jeong-Yong Park, Minha Kim, Wonchan Yoon, Soo-Im Choi and Dong Wook Shin
Cosmetics 2026, 13(1), 46; https://doi.org/10.3390/cosmetics13010046 - 18 Feb 2026
Viewed by 1260
Abstract
Oxidative stress–induced dysfunction of hair follicle dermal papilla cells (HFDPCs) is a key factor in the progression of hair loss. In this study, upcycled postbiotic cell-free supernatants (CFSs), derived from Limosilactobacillus fermentum (L. fermentum) MG901 and MG4237, which are typically discarded [...] Read more.
Oxidative stress–induced dysfunction of hair follicle dermal papilla cells (HFDPCs) is a key factor in the progression of hair loss. In this study, upcycled postbiotic cell-free supernatants (CFSs), derived from Limosilactobacillus fermentum (L. fermentum) MG901 and MG4237, which are typically discarded after fermentation, were evaluated for their protective effects in H2O2-damaged human dermal papilla cells. The CFS exhibited no cytotoxicity and significantly enhanced wound-healing capacity while suppressing intracellular reactive oxygen species accumulation under oxidative stress conditions. In addition, treatment with CFS restored mitochondrial function, indicating recovery from H2O2-induced cellular damage. Dermal papilla cell-specific functional markers, including alkaline phosphatase activity, were also significantly increased following treatment. Mechanistic analyses further revealed that these protective effects were associated with modulation of Wnt/β-catenin signaling as well as regulation of mitochondrial function. Collectively, these findings suggest that upcycled postbiotic CFS from L. fermentum MG901 and MG4237 mitigates oxidative stress-induced dermal papilla cell dysfunction, supporting its potential application as a sustainable cosmetic ingredient for alleviating hair loss. Full article
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