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Colloids and Interfaces
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Biocolloids and Biointerfaces: 3rd Edition
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Biocolloids and Biointerfaces: 3rd Edition

A special issue of Colloids and Interfaces (ISSN 2504-5377).

Deadline for manuscript submissions: 1 September 2026 | Viewed by 3934

Special Issue Editors

Dr. Aleksandra Szcześ

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Guest Editor
Department of Interfacial Phenomena, Faculty of Chemistry, Institute of Chemical Science, Maria Curie-Sklodowska University, M.C.-Sklodowska Sq. 3/114, 20-031 Lublin, Poland
Interests: colloid and interface science; biomaterials and nanomaterials; liposomes
Special Issues, Collections and Topics in MDPI journals
Dr. Reinhard Miller

E-Mail Website
Guest Editor
Institute for Condensed Matter Physics, Technical University Darmstadt, D-64289 Darmstadt, Germany
Interests: dynamics and mechanics of liquid interfaces; thermodynamics of adsorption of surfactants and proteins; interfacial interactions and 2D rheology; stability of foams and emulsions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biocolloids and biointerfaces are key aspects in the multidisciplinary research field where the fundamentals of colloid and interface science meet naturally occurring or bioinspired systems. This multidisciplinary complexity demands insights and input from biology, pharmacy, and medicine, in addition to classic colloid and surface chemistry. Progress in this area will require collaboration from these different disciplines, creating scientific synergy. Such advancement of the knowledge of biocolloids and biointerfaces is highly relevant and, indeed, urgent. This Special Issue, following the success of the first and second editions, aims to provide a forum for the dissemination of the latest information on aerosols to understand the infection route, the impact of particle-like viruses on the mucus layer in the lung, as formed and stabilized by pulmonary surfactants, the route for the treatment of lung diseases, and the design of face masks to optimize their efficacy.

Dr. Aleksandra Szcześ
Dr. Reinhard Miller
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Colloids and Interfaces is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioinspired colloids and interfaces
  • interfacial properties of adsorbed biosurfactants and biopolymers
  • pulmonary surfactants—micelles and vesicles as delivery systems
  • bacteria and viruses as colloidal systems
  • biochemical and tissue engineering
  • soft matter in food
  • model membranes
  • bioaerosols

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Published Papers (3 papers)

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Research

20 pages, 1080 KB  
Article
Rational Design of Lecithin–Cholesterol Liposomes for Encapsulation and Sustained Release of Diclofenac
by Ángela Sánchez-García, Francisco Ortega, Ramón G. Rubio and Eduardo Guzmán
Colloids Interfaces 2026, 10(2), 25; https://doi.org/10.3390/colloids10020025 - 4 Mar 2026
Viewed by 1363
Abstract
Liposomes are widely recognized as versatile nanocarriers in drug delivery due to their biocompatibility, tunable physicochemical properties, and ability to incorporate both hydrophilic and hydrophobic compounds. In this study, the encapsulation and release of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), using lecithin–cholesterol liposomes [...] Read more.
Liposomes are widely recognized as versatile nanocarriers in drug delivery due to their biocompatibility, tunable physicochemical properties, and ability to incorporate both hydrophilic and hydrophobic compounds. In this study, the encapsulation and release of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), using lecithin–cholesterol liposomes are explored. Encapsulation parameters were first optimized with calcein as a model fluorophore, confirming that cholesterol addition enhances encapsulation efficiency by reducing membrane permeability. Guided by these results, liposomes containing equal weight fractions of lecithin and cholesterol were selected as an optimized formulation, providing calcein and diclofenac encapsulation efficiencies up to approximately 35% while maintaining hydrodynamic diameters below 300 nm with low polydispersity (PdI < 0.2), optimal for intravenous administration and prolonged systemic circulation. Release studies demonstrated sustained drug release over 15 days, with cumulative release exceeding 80%. Weibull modeling yielded θ∞ ≈ 1 and β values up to ~1.6 at higher loadings, with β > 1 indicating a complex, sigmoidal (non-Fickian) release mechanism. These findings support the potential of liposomes as delivery platforms for NSAIDs with solubility and bioavailability limitations. Full article
(This article belongs to the Special Issue Biocolloids and Biointerfaces: 3rd Edition)
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19 pages, 3798 KB  
Article
Tuning Antigen–Adjuvant Interactions by Modulating the Physicochemical Properties of Aluminum Hydroxide Nanoparticles for Improved Antigen Stability
by Khaleda C. Rinee, Jan Ilavsky, Ivan Kuzmenco, Xiaobing Zuo and Amy Y. Xu
Colloids Interfaces 2026, 10(1), 16; https://doi.org/10.3390/colloids10010016 - 4 Feb 2026
Viewed by 1069
Abstract
Adjuvants are chemical substances used in vaccines to enhance immunogenicity. Among them, aluminum-based nanoparticles are some of the oldest and most widely employed adjuvants in vaccine formulations. A key function of aluminum adjuvants is thought to involve acting as an antigen depot, enabling [...] Read more.
Adjuvants are chemical substances used in vaccines to enhance immunogenicity. Among them, aluminum-based nanoparticles are some of the oldest and most widely employed adjuvants in vaccine formulations. A key function of aluminum adjuvants is thought to involve acting as an antigen depot, enabling slow antigen release and providing sufficient time for effective immune activation. Therefore, understanding antigen–adjuvant interactions is essential, as these interactions influence antigen stability, release kinetics, and overall vaccine performance. In this study, we investigated how the physicochemical properties of aluminum hydroxide nanoparticles modulate antigen–protein interactions and affect protein stability. Nanoparticles synthesized under acidic (pH ≈ 5.0) to near-neutral (pH ≈ 7.1) conditions exhibited lower crystallinity, reduced hydroxyl density, and higher interfacial hydration, whereas those prepared under basic conditions (pH ≈ 9.0) displayed increased crystallinity, enriched surface hydroxyl groups, and markedly reduced hydration. Antigen proteins bound to low-crystallinity aluminum hydroxide nanoparticles showed improved thermal stability, while those associated with highly crystalline nanoparticles exhibited reduced thermal stability. Complementary ITC study further suggests that these stability differences are accompanied by changes in their interaction behavior. These findings indicate that the structural and interfacial properties of aluminum hydroxide nanoparticles strongly influence their interactions with antigen proteins and the resulting physical stability. Together, our results demonstrate that the balance among crystallinity, hydroxyl organization, and interfacial hydration governs the thermal behavior of antigen proteins adsorbed onto aluminum hydroxide. This work provides a rational design principle for engineering aluminum-based adjuvants that optimize antigen–protein stability in vaccine formulations. Full article
(This article belongs to the Special Issue Biocolloids and Biointerfaces: 3rd Edition)
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22 pages, 5019 KB  
Article
Enhanced Bioactivity and Antibacterial Properties of Ti-6Al-4V Alloy Surfaces Modified by Electrical Discharge Machining
by Bárbara A. B. dos Santos, Rafael E. G. Leal, Ana P. G. Gomes, Liszt Y. C. Madruga, Ketul C. Popat, Hermes de Souza Costa and Roberta M. Sabino
Colloids Interfaces 2026, 10(1), 12; https://doi.org/10.3390/colloids10010012 - 22 Jan 2026
Cited by 1 | Viewed by 948
Abstract
Bacterial infections and the lack of bioactivity of titanium implants and their alloys remain critical challenges for the long-term performance and clinical success of these devices. These issues arise from the undesirable combination of early microbial adhesion and the limited ability of metallic [...] Read more.
Bacterial infections and the lack of bioactivity of titanium implants and their alloys remain critical challenges for the long-term performance and clinical success of these devices. These issues arise from the undesirable combination of early microbial adhesion and the limited ability of metallic surfaces to form a bioactive interface capable of supporting osseointegration. To address these limitations simultaneously, this study employed electrical discharge machining (EDM), which enables surface topography modification and in situ incorporation of bioactive ions from the dielectric fluid. Ti-6Al-4V ELI surfaces were modified using two dielectric fluids, a fluorine/phosphorus-based solution (DF1-F) and a calcium/phosphorus-based solution (DF2-Ca), under positive and negative polarities. The recast layer was characterized by SEM and EDS, while bioactivity was evaluated through immersion in simulated body fluid (SBF) for up to 21 days. Antibacterial performance was assessed against Staphylococcus aureus at 6 h and 24 h of incubation. The results demonstrated that dielectric composition and polarity strongly influenced ionic incorporation and the structural stability of the modified layers. The DF2-Ca(+) condition exhibited the most favorable bioactive response, with Ca/P ratios closer to hydroxyapatite and surface morphologies typical of mineralized coatings. In antibacterial assays, Ca/P-containing surfaces significantly decreased S. aureus attachment (>80–90%). Overall, EDM with Ca/P-containing dielectrics enables the fabrication of Ti-6Al-4V surfaces with enhanced mineralization capacity and anti-adhesive effects against Gram-positive bacteria, reinforcing their potential for multifunctional biomedical applications. Full article
(This article belongs to the Special Issue Biocolloids and Biointerfaces: 3rd Edition)
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