Research and Development of Thin Films and Nanostructures for Biological Applications

A Special Issue of Coatings (ISSN 2079-6412) belonging to the section "Thin Films".

Deadline for manuscript submissions: 31 January 2027 | Viewed by 2126

Editors


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Guest Editor
Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland
Interests: photodynamic therapy (PDT); photophysics; the design and development of liposomal drug carriers; the role of metal chelators in medicine and nanotechnology

E-Mail Website
Guest Editor
Institute of Physics, Faculty of Science and Technology, University of Silesia in Katowice, 75 Pułku Piechoty 1a, 41-500 Chorzów, Poland
Interests: molecular biology; biocompatibility of materials; photodynamic therapy; iron metabolism in cancer; mitochondrial dynamics; confocal microscopy; electron microscopy

E-Mail Website
Guest Editor
Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia, Jagiellońska Str. 28, 40-032 Katowice, Poland
Interests: nanoparticles/nanomaterials synthesis; coating nanostructures on organic polymers; microbial-nanostructures interactions at the molecular level; biochemistry; genetic; toxicology; oxidative stress metabolism; biosafty and biocompability; nanomedicine

Special Issue Information

Dear Colleagues,

Advances in thin films and nanostructures are opening new frontiers in the fields of biology and medicine. The unique surface and interface properties of these materials play a critical role in their performance across a range of biological applications, from biosensing and drug delivery to tissue engineering and antimicrobial coatings. Of particular interest are nanocarriers—such as liposomes, polymeric nanoparticles, and dendrimers—which are increasingly engineered with functional coatings to enhance biocompatibility, targeting, and controlled release.

This Special Issue aims to highlight the latest developments in the design, fabrication, and characterization of thin films and nanostructures with a focus on their interaction with biological environments. We invite contributions that explore both fundamental research and innovative applications, with the goal of advancing sustainable, functional, and biocompatible solutions for healthcare and life sciences.

Dr. Patrycja Rawicka
Dr. Robert Gawecki
Dr. Daniel Wasilkowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Coatings is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible coatings
  • antimicrobial surfaces
  • thin films in biomedical applications
  • nanocarriers for drug delivery
  • functional nanostructures

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Published Papers (1 paper)

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Research

36 pages, 21920 KB  
Article
Ag–ZnO and Cu–ZnO Nanocomposites as Dual-Function Agents: Antifungal Activity and Cytotoxic Effects in MDA-MB-231 Breast Cancer Cells
by Mohamed I. Ahmed, Aleksandra Zielińska, Monika Paul-Samojedny, Anna Nowak, Mateusz Dulski, Aleksandra Strach, Izabela Potocka, Krzysztof Matus and Daniel Wasilkowski
Coatings 2026, 16(6), 690; https://doi.org/10.3390/coatings16060690 - 10 Jun 2026
Viewed by 1689
Abstract
Rising triple-negative breast cancer (TNBC) cases and Candida infection risks during chemotherapy demand novel therapies, with metal-oxide nanocomposites emerging as a promising solution. In this study, we synthesized Ag-ZnO and Cu-ZnO nanocomposites as established quantitative links between their physicochemical properties, ion release behaviour, [...] Read more.
Rising triple-negative breast cancer (TNBC) cases and Candida infection risks during chemotherapy demand novel therapies, with metal-oxide nanocomposites emerging as a promising solution. In this study, we synthesized Ag-ZnO and Cu-ZnO nanocomposites as established quantitative links between their physicochemical properties, ion release behaviour, and biological activity, evaluating antifungal effects against Candida albicans (ATCC 90028) and Saccharomyces cerevisiae (ATCC 9763), and their anticancer potential against MDA-MB-231 cells (ATCC HTB-26). The results revealed Ag (~13–19 nm) and Cu (~4–8 nm) nanoparticles dispersed in a ZnO matrix, with XPS confirming mixed Ag0/Ag(I)/Ag(III) and Cu(I)/Cu(II) speciation. Ag-ZnO NC exhibited strong antifungal activity (MIC = 25 mg L−1) against both fungi, while Cu-ZnO NC was only effective (MIC = 100 mg L−1) against S. cerevisiae. Aqueous release of Ag+ was ~2.6-fold higher than Cu2+. Ag-ZnO NC induced marked ROS generation (~6-fold higher than S. cerevisiae) and dehydrogenase inhibition (6.6- and ~20-fold, respectively). ATR-FTIR linked species-specific susceptibility to cell-wall architecture. SEM confirmed membrane destabilization and perforation. In MDA-MB-231, necrotic fractions reached ~9% and >40% for Ag-ZnO and Cu-ZnO, respectively. Both metal oxide nanocomposites (MONCs) act through ion release, revealing a selectivity window, especially for Ag-ZnO. Further studies on non-cancerous cells, ion-release kinetics, uptake and in vivo validation are essential to establish a therapeutic index. Full article
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